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(+/-)-Lisofylline

Cat. No. M10573
(+/-)-Lisofylline Structure
Synonym:

Penthydroxifillyne

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1mg USD 90  USD90 1-2 Weeks
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Quality Control & Documentation
Biological Activity

(±)-Lisofylline is a potent anti-inflammatory agent in which only the (-) optical isomer is biologically active. (±)-Lisofylline was found to inhibit the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase. Lisofylline was able to suppress IFN-γ production, reduce the onset of insulitis and diabetes, and inhibit diabetes.

Chemical Information
Molecular Weight 280.32
Formula C13H20N4O3
CAS Number 6493-06-7
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Z-D Yang, et al. Diabetologia. The anti-inflammatory compound lisofylline prevents Type I diabetes in non-obese diabetic mice

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Keywords: (+/-)-Lisofylline, Penthydroxifillyne supplier, Immunology/Inflammation, inhibitors, activators

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