Free shipping on all orders over $ 500

(+/-)-Lisofylline

Cat. No. M10573
(+/-)-Lisofylline Structure
Synonym:

Penthydroxifillyne

Size Price Availability
1mg USD 90  USD90 1-2 Weeks
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

(±)-Lisofylline is a potent anti-inflammatory agent in which only the (-) optical isomer is biologically active. (±)-Lisofylline was found to inhibit the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase. Lisofylline was able to suppress IFN-γ production, reduce the onset of insulitis and diabetes, and inhibit diabetes.

Chemical Information
Molecular Weight 280.32
Formula C13H20N4O3
CAS Number 6493-06-7
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Z-D Yang, et al. Diabetologia. The anti-inflammatory compound lisofylline prevents Type I diabetes in non-obese diabetic mice

Related Immunology/Inflammation Products
BK50164

BK50164 is a potent CD73 inhibitor with an IC50 value of 13.089 µM.

CCT374705

CCT374705 is an orally active BCL6 inhibitor with potent antiproliferative effects in vitro.

Mycophenolate Sodium

Mycophenolate Sodium is a Mycophenolic acid precursor, as well as an inhibitor of T-lymphocyte proliferation and an inhibitor of inosine monophosphate dehydrogenase (IMPDH).

Efgartigimod

Efgartigimod (ARGX-113) is a human IgG1 antibody Fc-derived fragment and an Fc receptor antagonist that can be used in studies related to autoimmune diseases such as myasthenia gravis (MG), primary immune thrombocytopenia (ITP), and others.

DiaPep277

DiaPep277 is a peptide containing 24 amino acids based on residues 437 to 460 of Heat Shock Protein 60 (HSP60) for studies related to the immune system in type 1 diabetes.

  Catalog
Abmole Inhibitor Catalog




Keywords: (+/-)-Lisofylline, Penthydroxifillyne supplier, Immunology/Inflammation, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.