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Eriodictyol is a flavonoid obtained from Chinese herbs, which has antioxidant and anti-inflammatory properties. Eriodictyol can induce Nrf2 signaling pathway. Eriodictyol is also an influenza dependent RNA polymerase inhibitor with an IC50 of 18 nM.
Eriodictyol (20, 40, 80 μM) protects primary cultured cortical neurons against Aβ25-35-induced cytotoxicity and cell apoptosis via the Nrf2/ARE pathway. Eriodictyol (80 μM) induces nuclear expression of Nrf2 and the expression of ARE-regulated genes in primary cultured cortical neurons.
Eriodictyol (30 mg/kg, p.o.) decreases the production of inflammatory cytokines, elevates survival rate, and decreases oxidative stress levels in LPS-induced ALI mice. Eriodictyol inhibits MPO activity and inflammatory neutrophil accumulation in the lung tissues.
| Molecular Weight | 288.25 |
| Formula | C15H12O6 |
| CAS Number | 552-58-9 |
| Solubility (25°C) | DMSO 87 mg/mL |
| Storage | 2-8°C, protect from light |
[1] Shu Wen, et al. Effect of Eriodictyol on Retinoblastoma via the PI3K/Akt Pathway
[5] Anowarul Islam, et al. The pharmacological and biological roles of eriodictyol
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