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Eriodictyol

Cat. No. M4686
Eriodictyol Structure
Size Price Availability Quantity
5mg USD 75  USD75 In stock
10mg USD 105  USD105 In stock
20mg USD 150  USD150 In stock
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Quality Control & Documentation
Biological Activity

Eriodictyol is a flavonoid obtained from Chinese herbs, which has antioxidant and anti-inflammatory properties. Eriodictyol can induce Nrf2 signaling pathway. Eriodictyol is also an influenza dependent RNA polymerase inhibitor with an IC50 of 18 nM.

Chemical Information
Molecular Weight 288.25
Formula C15H12O6
CAS Number 552-58-9
Solubility (25°C) 10 mM in DMSO
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shu Wen, et al. Effect of Eriodictyol on Retinoblastoma via the PI3K/Akt Pathway

[2] Chuanxiang Wang, et al. Eriodictyol Attenuates MCAO-Induced Brain Injury and Neurological Deficits via Reversing the Autophagy Dysfunction

[3] Zirong Deng, et al. Pharmacological Activity of Eriodictyol: The Major Natural Polyphenolic Flavanone

[4] Lei Zhang, et al. Eriodictyol produces antidepressant-like effects and ameliorates cognitive impairments induced by chronic stress

[5] Anowarul Islam, et al. The pharmacological and biological roles of eriodictyol

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