All AbMole products are for research use only, cannot be used for human consumption.
TAPI blocks the spontaneous and PMA-induced release of TNF-alpha from transfected cells. TAPI-1, an inhibitor of ADAMs, reduced constitutive and muscarinic receptor-stimulated sAPP alpha release in HEK-293 cells stably expressing M3 muscarinic receptors. TAPI-1 with the EGFR inhibitor AG1478 exhibits deactivated AREG/EGFR/ERK signaling pathway and reduces pro-inflammatory cytokines release in pSS salivary gland-derived epithelial cells.
| Cell Experiment | |
|---|---|
| Cell lines | LI90 cells |
| Preparation method | Seeding five thousand cells into each well of 96-well plates and assessing their viability by CellTiter-Glo Luminescent Cell Viability assay. Upon serum deprivation for 24 h, tresting the cells with Ang II for 60 h with and without pretreatment with each inhibitor and antagonist. Then addint The assay substrates to each well on the plate and using a luminometer to evaluate the samples |
| Concentrations | 20 μM |
| Incubation time | 60 hours |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 499.60 |
| Formula | C26H37N5O5 |
| CAS Number | 171235-71-5 |
| Solubility (25°C) | DMSO ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Immunology/Inflammation Products |
|---|
| Daratumumab
Daratumumab (Daratumumab) is a first-in-class, specific anti-CD38 monoclonal antibody (IgG1). (for human or immunodeficient mice). |
| Laquinimod
Laquinimod (ABR-215062) is a new orally active immunoregulator effectively inhibits development and relapses of experimental autoimmune encephalomyelitis. |
| Mycophenolic acid
Mycophenolic acid is an immunosuppressant agent used to prevent rejection in organ transplantation. |
| Dipsacoside B
Dipsacoside B is extracted from Lonicara confusa DC. dried buds and flowers. Dipsacoside B showes strong antimicrobial activity. |
| Edpetiline
Edpetiline is a major alkaloid from P. Eduardi. Edpetiline has significant anti-inflammatory effects. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
