About 11 results found for searched term "TAPI-1" (0.128 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3634 | TAPI-1 | Immunology/Inflammation |
| TAPI-1 is an ADAM17/TACE inhibitor that blocks shedding of cytokine receptors with IC50 value of 8.09 microM. | ||
| M57874 | Florbetapir F-18 | Others |
| Florbetapir F-18 | ||
| M2208 | Lomitapide | Others |
| AEGR-733, BMS-201038 | ||
| Lomitapide (AEGR-733, BMS-201038) is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM. | ||
| M4463 | Abametapir | MMP |
| HA-44; BRN 0123183; 5,5′-Dimethyl-2,2′-dipyridyl | ||
| Abametapir (HA-44, BRN 0123183) is an inhibitor of metalloproteinases critical for louse survival and egg development. | ||
| M5786 | Metyrapone | Metabolite/Endogenous Metabolite |
| Metapirone; Su-4885 | ||
| Metyrapone (Metapirone) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone (Metapirone) inhibits cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1. | ||
| M6216 | TAPI-2 | MMP |
| TAPI-2 is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20±10 μM for MMP. | ||
| M8932 | Eptapirone | 5-HT Receptor |
| F11440 | ||
| Eptapirone (F11440) is a potent 5HT(1A) receptor agonist with marked anxiolytic and antidepressant potential. | ||
| M10941 | Tapinarof | Aryl hydrocarbon Receptor |
| WBI-1001; Benvitimod; GSK2894512 | ||
| Tapinarof (WBI-1001) is a Frist in class aromatic hydrocarbon receptor (AhR) agonist with EC50 of 13 nM. Tapinarof reduced skin inflammation in mice. It can effectively inhibit inflammatory cytokines, regulate skin barrier protein expression and antioxidant activity. | ||
| M27941 | AV-105 | Others |
| AV-105 is a Florbetapir (18F)-radiolabeled slyrylpyridine tosylate precursor extracted from patent WO2010078370A1, example 1.5. AV-105 can synthesize 18F-radiolabeled compounds, which are used for positron emission tomography (PET) imaging of neurodegenerative diseases of the brain. | ||
| M30940 | Flobetapir | Others |
| AV-45 | ||
| Flobetapir (AV-45) may be a well-tolerated imaging agent. Flobetapir synthesizes Florbetapir (18F) that is a PET scanning radiopharmaceutical compound containing the radionuclide fluorine-18. | ||
| M55908 | TAPI-0 | TNF Receptor |
| TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC50 of 100 nM. | ||
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