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Daratumumab

Cat. No. M1616

All AbMole products are for research use only, cannot be used for human consumption.

Daratumumab Structure
Synonym:

DARA

Size Price Availability Quantity
100ug USD 130 In stock
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Quality Control & Documentation
Biological Activity

Daratumumab is the first IgG1k monoclonal antibody that targets CD38 directly in human and immunodeficient mice.CD38 is overexpressed in multiple myeloma cells. Daratumumab binds to CD38, causing cells to apoptose via antibody-dependent cellular cytotoxicity or complement-dependent cytotoxicity.

Chemical Information
Molecular Weight 145389.23
Formula C6466H9996N1724O2010S42
CAS Number 945721-28-8
Storage -80°C for long term
References

[1] Matas-Cespedes A, et al. Clin Cancer Res. The Human CD38 Monoclonal Antibody Daratumumab Shows Antitumor Activity and Hampers Leukemia–Microenvironment Interactions in Chronic Lymphocytic Leukemia.

[2] Lokhorst HM, et al. N Engl J Med. Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma.

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Keywords: Daratumumab, DARA supplier, Immunology/Inflammation, inhibitors, activators

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