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Pimecrolimus is an immunomodulating agent used in the treatment of atopic dermatitis. Pimecrolimus binds to macrophilin-12(also referred to as FKBP-12) and inhibits calcineurin in vitro. Pimecrolimus inhibits T-cell activation by inhibiting the synthesis and release of cytokines from T-cells.
| Molecular Weight | 810.45 |
| Formula | C43H68ClNO11 |
| CAS Number | 137071-32-0 |
| Solubility (25°C) | DMSO 120 mg/mL Ethanol 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] T Luger, et al. Topical therapy of atopic dermatitis with a focus on pimecrolimus
[2] Matthew Ladda, et al. Off-label Uses of Topical Pimecrolimus
[3] Jean Ayer, et al. Pimecrolimus for psoriasis
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