Pimecrolimus is an immunomodulating agent used in the treatment of atopic dermatitis. Pimecrolimus binds to macrophilin-12(also referred to as FKBP-12) and inhibits calcineurin in vitro. Pimecrolimus inhibits T-cell activation by inhibiting the synthesis and release of cytokines from T-cells.
| Molecular Weight | 810.45 |
| Formula | C43H68ClNO11 |
| CAS Number | 137071-32-0 |
| Solubility (25°C) | DMSO 120 mg/mL Ethanol 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] T Luger, et al. Topical therapy of atopic dermatitis with a focus on pimecrolimus
[2] Matthew Ladda, et al. Off-label Uses of Topical Pimecrolimus
[3] Jean Ayer, et al. Pimecrolimus for psoriasis
| Related Immunology/Inflammation Products |
|---|
| Lobenzarit
Lobenzarit is an immunomodulator, possesses anti-oxidative. |
| ORIC-533
ORIC-533 is a highly potent and selective, orally bioavailable, Best-in-Class small molecule inhibitor of CD73, an enzyme expressed by various cell types, including immune cells and which catalyzes the generation of adenosine from adenosine monophosphate (AMP). |
| Naringenin
Naringenin is the predominant flavanone in Citrus reticulata Blanco, it displays strong anti-inflammatory and antioxidant activities. Naringenin has anti-dengue virus (DENV) activity. |
| BK50164
BK50164 is a potent CD73 inhibitor with an IC50 value of 13.089 µM. |
| CCT374705
CCT374705 is an orally active BCL6 inhibitor with potent antiproliferative effects in vitro. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
