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Leonurine hydrochloride

Cat. No. M4724
Leonurine hydrochloride Structure

SCM-198 hydrochloride

Size Price Availability Quantity
10mg USD 92  USD92 In stock
20mg USD 192  USD192 In stock
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Quality Control & Documentation
Biological Activity

Leonurine hydrochloride is an alkaloid isolated from Herba leonuri, with anti-oxidative and anti-inflammatory.

Customer Product Validations & Biological Datas
Source Bone (2015). Figure 2. Leonurine-hydrochloride
Method qRT-PCR
Cell Lines RAW264.7 cells
Concentrations 2 μM
Incubation Time 24 h
Results The mRNA expression of RANK was upregulated in M-CSF treated BMMs. LH treatment significantly suppressed RANK mRNA expression in BMMs
Source Bone (2015). Figure 1. Leonurine-hydrochloride
Method osteoclastogenesis assay
Cell Lines RAW264.7 cells
Concentrations 2 μM
Incubation Time 5 d
Results LH inhibited osteoclastogenesis in both RAW 264.7 cells (Fig. 1A) and BMMs (Fig. 1B) in a dose-dependent manner from 0.5–2 μM.
Protocol (for reference only)
Cell Experiment
Cell lines RAW 264.7 cells
Preparation method RAW 264.7 cells were seeded in a 6-cm dish and pretreated with different concentrations of LH (2 μM) for 6 h, and then stimulated with RANKL (100 ng/mL) for 15 min. The cells were washed with icecold PBS and lysed in radioimmunoprecipitation assay (RIPA) buffer.
Concentrations 2 μM
Incubation time 6 h
Animal Experiment
Animal models Male Sprague-Dawley rats
Formulation 0.5% sodium carboxymethyl cellulose (CMC) solution
Dosages 30 mg/kg
Administration oral
Chemical Information
Molecular Weight 347.79
Formula C14H21O5N3.HCl
CAS Number 24735-18-0
Solubility (25°C) Water 4 mg/mL
DMSO 24 mg/mL
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Yuan FL, et al. Bone. Leonurine hydrochloride inhibits osteoclastogenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-κB and PI3K/Akt signaling pathways.

[2] Zhu Q, et al. ScientificWorldJournal. Characterization of metabolites of leonurine (SCM-198) in rats after oral administration by liquid chromatography/tandem mass spectrometry and NMR spectrometry.

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Keywords: Leonurine hydrochloride, SCM-198 hydrochloride supplier, Immunology/Inflammation, inhibitors, activators

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