Leonurine hydrochloride

Cat. No. M4724

All AbMole products are for research use only, cannot be used for human consumption.

Synonym:

SCM-198 hydrochloride

Size	Price	Availability	Quantity
10mg	USD 92 USD92	In stock
20mg	USD 192 USD192	In stock

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Leonurine hydrochloride is an alkaloid isolated from Herba leonuri, with anti-oxidative and anti-inflammatory.

	Source	Bone (2015). Figure 2. Leonurine-hydrochloride
	Method	qRT-PCR
	Cell Lines	RAW264.7 cells
	Concentrations	2 μM
	Incubation Time	24 h
	Results	The mRNA expression of RANK was upregulated in M-CSF treated BMMs. LH treatment significantly suppressed RANK mRNA expression in BMMs

	Source	Bone (2015). Figure 1. Leonurine-hydrochloride
	Method	osteoclastogenesis assay
	Cell Lines	RAW264.7 cells
	Concentrations	2 μM
	Incubation Time	5 d
	Results	LH inhibited osteoclastogenesis in both RAW 264.7 cells (Fig. 1A) and BMMs (Fig. 1B) in a dose-dependent manner from 0.5–2 μM.

Cell Experiment
Cell lines	RAW 264.7 cells
Preparation method	RAW 264.7 cells were seeded in a 6-cm dish and pretreated with different concentrations of LH (2 μM) for 6 h, and then stimulated with RANKL (100 ng/mL) for 15 min. The cells were washed with icecold PBS and lysed in radioimmunoprecipitation assay (RIPA) buffer.
Concentrations	2 μM
Incubation time	6 h

Animal Experiment
Animal models	Male Sprague-Dawley rats
Formulation	0.5% sodium carboxymethyl cellulose (CMC) solution
Dosages	30 mg/kg
Administration	oral

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