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Carnosol

Cat. No. M4389
Carnosol Structure
Size Price Availability Quantity
5mg USD 50  USD50 In stock
10mg USD 70  USD70 In stock
25mg USD 140  USD140 In stock
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Quality Control & Documentation
Biological Activity

Carnosol is a naturally occurring phyto polyphenol[1]or phenolic diterpene, which can show a broad spectrum of applications as a an antioxidant, anticancer agent and anti-inflammatory agent. Carnosol is one of the phenolic antioxidants present in extracts of the herb rosemary (Rosmarinus officinalis). Carnosol inhibits the formation of tumors derived using irritants such as TPA and DMBA in murine models of carcinogenesis. The effective dose reported is 1-10 μM topically or 6 μg/ml when added to supernatants of cultured cells.

Chemical Information
Molecular Weight 330.42
Formula C20H26O4
CAS Number 5957-80-2
Storage -20°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Huang SC, et al. Biochem Pharmacol. Carnosol inhibits the invasion of B16/F10 mouse melanoma cells by suppressing metalloproteinase-9 through down-regulating nuclear factor-kappa B and c-Jun.

[2] Lo AH, et al. Carcinogenesis. Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages.

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