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SKQ1 

Cat. No. M4825
SKQ1  Structure
Synonym:

Visomitin; PDTP

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 48  USD48 In stock
10mg USD 77  USD77 In stock
25mg USD 145  USD145 In stock
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Quality Control & Documentation
Biological Activity

SKQ1 prevents amyloid-β-induced impairment of long-term potentiation in rat hippocampal slices.SKQ1 reverses aging-related biomarkers in rats.SKQ1 slows down the development of age-dependent destructive processes in retina and vascular layer of eyes of wistar and OXYS rats.SKQ1 increases the lifespan of male rodents under LP or SPF conditions.SKQ1 can penetrate cell membranes, and is proposed as an anti-aging treatment.Pretreatment of rats with mitochondria-targeted antioxidant SkQ1 (50 nmol/kg during 5 days) significantly increased the mRNA levels of Nrf2 transcription factor and Nrf2-induced genes encoding antioxidant enzymes SOD1, SOD2, CAT, and GPx4 in rat peripheral blood leukocytes. The increase in expression of these genes with SkQ1 addition was accompanied by increased activities of catalase, glutathione peroxidase, and glutathione-S-transferase in leukocytes.

Customer Product Validations & Biological Datas
Source Biochemistry (Mosc) (2017). Figure 2. SKQ1
Method i.e.
Cell Lines SPF mice of the C57BL/6
Concentrations 1000 nmol/kg
Incubation Time 7 d
Results Administration of SkQ1, which started on the 5th day of intoxication, prevented the decrease in motor activity, the values being significantly different from the MPTP group
Chemical Information
Molecular Weight 617.60
Formula C36H42BrO2P
CAS Number 934826-68-3
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Vnukov VV, et al. Biochemistry (Mosc). Influence of SkQ1 on Expression of Nrf2 Transcription Factor Gene, ARE-Controlled Genes of Antioxidant Enzymes and Their Activity in Rat Blood Leukocytes.

[2] Samuilov VD, et al. Biochemistry (Mosc). Effect of cationic plastoquinone SkQ1 on electron transfer reactions in chloroplasts and mitochondria from pea seedlings.

[3] Iomdina EN, et al. Front Biosci (Landmark Ed). Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits.

[4] Manskikh VN, et al. Biochemistry (Mosc). Effect of the mitochondria-targeted antioxidant SkQ1 on development of spontaneous tumors in BALB/c mice.

[5] Myasoedova KN, et al. Biochemistry (Mosc). Therapeutic doses of SkQ1 do not induce cytochromes P450 in rat liver.

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Keywords: SKQ1 , Visomitin; PDTP supplier, Immunology/Inflammation, inhibitors, activators


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