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SKQ1 prevents amyloid-β-induced impairment of long-term potentiation in rat hippocampal slices.SKQ1 reverses aging-related biomarkers in rats.SKQ1 slows down the development of age-dependent destructive processes in retina and vascular layer of eyes of wistar and OXYS rats.SKQ1 increases the lifespan of male rodents under LP or SPF conditions.SKQ1 can penetrate cell membranes, and is proposed as an anti-aging treatment.Pretreatment of rats with mitochondria-targeted antioxidant SkQ1 (50 nmol/kg during 5 days) significantly increased the mRNA levels of Nrf2 transcription factor and Nrf2-induced genes encoding antioxidant enzymes SOD1, SOD2, CAT, and GPx4 in rat peripheral blood leukocytes. The increase in expression of these genes with SkQ1 addition was accompanied by increased activities of catalase, glutathione peroxidase, and glutathione-S-transferase in leukocytes.
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Source | Biochemistry (Mosc) (2017). Figure 2. SKQ1 |
| Method | i.e. | |
| Cell Lines | SPF mice of the C57BL/6 | |
| Concentrations | 1000 nmol/kg | |
| Incubation Time | 7 d | |
| Results | Administration of SkQ1, which started on the 5th day of intoxication, prevented the decrease in motor activity, the values being significantly different from the MPTP group |
| Molecular Weight | 617.60 |
| Formula | C36H42BrO2P |
| CAS Number | 934826-68-3 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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