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 About 30 results found for searched term "TRP Channel" (0.064 seconds)

Cat.No.  Name Target
M2591 Icilin TRP Channel
AG 3-5
Icilin is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel.
M3366 Amiloride hydrochloride dihydrate Sodium Channel
MK-870 hydrochloride dihydrate
Amiloride Hydrochloride Dihydrate (MK-870 Hydrochloride Dihydrate) is an inhibitor of epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is polycystin-2 (PC2; TRPP2) channel blocker.
M5205 ML204 Calcium Channel
ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
M5301 (E)-Cardamonin NLR
Alpinetin chalcone
(E)-Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM, Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.
M6380 A 967079 TRP Channel
A 967079 is a selective TRPA1 channel blocker.
M6393 AC 4 TRP Channel
AC 4 is a photoswitchable TRPV1 channel blocker.
M6466 AS 1269574 GPR/FFAR
AS1269574 is a potent, orally active GPR119 agonist with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates the TRPA1 cation channel and stimulates glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induced pancreatic β cells to secrete glucose-dependent insulin only under high glucose conditions. AS1269574 has potential for type 2 diabetes research.
M6494 BCTC TRP Channel
BCTC is a tRPV1 antagonist. BCTC is also a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells.
M6705 EIPA TRP Channel
L593754; MH 12-43; Ethylisopropylamiloride
EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3).
M6983 ML SA1 TRP Channel
ML SA1 is a activator of TRPML channels.
M7151 Polygodial Others
Polygodial is a tRPA1 channel activator; analgesic and antifungal.
M7247 SAR7334 dihydrochloride Others
SAR 7334 2HCl
SAR7334 dihydrochloride is a novel, highly potent and bioavailable inhibitor of TRPC6 channels, inhibiting TRPC6 currents with IC50 of 7.9 nM.
M7303 SKF 96365 hydrochloride TRP Channel
SKF-96365 hydrochloride is a potent TRP channel blocker and SOCE (store-operated Ca2+ entry) inhibitor. It also induces cell cycle arrest and apoptosis in colorectal cancer cells.
M7313 SN 2 Others
SN 2 is a selective TRPML3 channel activator.
M7387 TCS 5861528 TRP Channel
Chembridge-5861528
TCS 5861528 (Chembridge-5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively.
M7577 ML-7 hydrochloride Others
ML-7 HCl
ML-7 hydrochloride is a naphthalene sulphonamide derivative, potently inhibits MLCK (IC50=300 nM) and TRPC6 channel (IC50>10 μM).
M7603 AP-18 TRP Channel
AP18
AP-18 is a selective TRPA1 channel blocker. AP-18 blocks activation of TRPA1 by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively.
M7816 GSK1016790A TRP Channel
GSK1016790A is a novel and potent TRPV4 channel agonist.
M7836 Hyperforin TRP Channel
Hyperforin is a transient receptor typical 6 (TRPC6) channel activator that regulates Ca2+ levels by activating Ca2+-transducing non-selective typical TRPC6 channels, with antidepressant and antitumor activities. In addition, Hyperforin modulates IL-17α secretion from γδ T cells and ameliorates Imiquimod-induced skin inflammation in psoriasis-like mice.
M8589 MSP-3 TRP Channel
MSP-3 is a Transient Receptor Potential Vanilloid Type-1 (TRPV1) channel agonist with antioxidant and neuroprotective activity.
M9089 SAR7334 Others
SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels.
M10039 GsMTx4 Peptides
GsMTx-4
GsMTx4 is a spider venom peptide that selectively inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families.
M10318 AC1903 TRP Channel
AC-1903
AC1903 is a specific inhibitor of TRPC5 channel.
M10625 GSK2193874 TRP Channel
GSK-2193874; GSK2193874A
GSK2193874 is a first-in-class orally bioavailable potent antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist with IC50 values of 2, 5, and 40 nM. GSK2193874 is the first-in-class orally bioavailable TRPV4 inhibitor that demonstrated ability to improve pulmonary functions in a number of heart failure models.
M10841 Mavatrep TRP Channel
JNJ-39439335
Mavatrep is an orally active TRPV1 antagonist with high affinity for the hTRPV1 channel, inhibits the binding of the TRPV1 agonist to [3H]-Resiniferatoxin (Ki=6.5 nM), and has a low effect on the enzymatic activity of CYP subtypes 3A4, 1A2, and 2D6.
M10927 GFB-8438 TRP Channel
GFB-8438 is a potent subtype selective TRPC5 inhibitor against hTRPC5 and hTRPC4 IC50 0.18 and 0.29 μM, respectively. GFB-8438 has good selectivity for TRPC6, other members of the TRP family, NaV1.5, and limited activity against hERG channels. Protective effect of GFB-8438 on mouse podocytes.
M11223 TRPM4-IN-1 TRP Channel
CBA, Compound 5, TRPM4 inhibitor 5
Trpm4-in-1 (CBA) is an effective and selective cationic channel TRPM4 inhibitor with an IC50 of 1.5 μM.
M14278 EIPA hydrochloride TRP Channel
L593754 hydrochloride; MH 12-43 hydrochloride
EIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
M14280 GSK2798745 TRP Channel
GSK2798745 is a first-in-class, highly potent, selective, orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker with IC50s of 1.8 and 1.6 nM for hTRPV4 and rTRPV4, respectively.
M14282 ML204 hydrochloride TRP Channel
ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels.



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