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SAR7334 dihydrochloride inhibited TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected. SAR7334 suppresses TRPC6-dependent acute hypoxic pulmonary vasoconstriction (HPV) in the isolated perfused mouse lung. SAR7334 dihydrochloride opens new opportunities for the investigation of TRPC channel function in vivo.
| Molecular Weight | 440.79 |
| Formula | C21H22ClN3O.2HCl |
| CAS Number | 1333207-63-8 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Regoli and Barabe. Pharmacol Rev. Pharmacology of bradykinin and related kinins.
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