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AS1269574 is a potent, orally active GPR119 agonist with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates the TRPA1 cation channel and stimulates glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induced pancreatic β cells to secrete glucose-dependent insulin only under high glucose conditions. AS1269574 has potential for type 2 diabetes research.
| Molecular Weight | 308.17 |
| Formula | C13H14BrN3O |
| CAS Number | 330981-72-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 30.82 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Ashcroft and Gribble. TiPS. New windows on the mechanism of action of KATP channel openers.
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