Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M55658 | ML-184 | ML-184 (CID2440433) is a selective GPR55 agonist with an EC50 of 250 nM and exhibits >100-fold selectivity for GPR55 over GPR35, CB1 and CB2. ML-184(CID2440433) increases proliferation of neural stem cells and promotes neuronal differentiation in vitro. |
| M55197 | CID1231538 | CID1231538 is a potent GPR35 antagonist, with IC50 of 0.55 μM. CID1231538 is a benzothiazole analogue. |
| M30063 | BAM(8-22) | BAM(8-22), a proteolytically cleaved product of proenkephalin A, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1, and induces scratching in mice in an Mrgpr-dependent manner. |
| M29193 | (R)-ZINC-3573 | (R)-ZINC-3573 is a selective Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist with an EC50 value of 740 nM. (R)-ZINC-3573 can be used as a MRGPRX2 probe for the research of pain and itch. |
| M22486 | AH-7614 | AH-7614 is a potent and selective FFA4 (GPR120) antagonist, with pIC50s of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. AH-7614 has selectivity for FFA4 over FFA1 (pIC50<4.6). AH-7614 is able to block effects of both the polyunsaturated ω-6 fatty acid linoleic acid and the synthetic FFA4 agonist. |
| M22361 | TP-024 | TP-024 (FTBMT) is a selective GPR52 agonist with an EC50 of 75 nM. |
| M21601 | Pamoic acid | Pamoic acid is a potent GPR35 agonist with EC50 at 79 nM. Pamoic acid has neuroprotective and anti-inflammatory properties. |
| M20180 | WAY-388798 | WAY-388798 is a agonist of free fatty acid receptor 1 (GPR40) |
| M10682 | TAK-041 | TAK-041 is a first-in-class, selective GPR139 agonist with an EC50 of 22 nM. TAK-041 can be used to study negative symptoms of schizophrenia. |
| M10642 | ML382 | ML382 is a potent and selective MrgX1 (Mas-related G protein-coupled receptor X1, MRGPRX1) positive allosteric modulator with EC50 of 190 nM. |
| M10634 | NE 52-QQ57 | NE 52-QQ57 is an orally available GPR4 antagonist with an IC50 of 70 nM. NE 52-QQ57 significantly inhibited the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2). |
| M10562 | GPR81 agonist 1 | GPR81 agonist 1 is a potent and highly selective GPR81 agonist, with EC50 values of 58 nM and 50 nM for human and mouse GPR81, respectively. |
| M10469 | MCH TFA (human, mouse, rat) | MCH TFA (human, mouse, rat) is a potent peptide agonist of MCH-R and exhibits binding IC50 values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. |
| M9494 | AF64394 | AF64394 is a selective GPR3 inverse agonist with a pIC50 of 7.3. |
| M9245 | GTPL5846 | GTPL5846 (6-OAU) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay. |
| M8948 | TUG-891 | TUG-891, a selective agonist of FFAR4/GPR120, promoted the intracellular triglyceride accumulation in a dose-dependent manner. |
| M8822 | TUG-424 | TUG-424 is a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC50 of 32 nM. TUG-424 significantly increases glucose-stimulated insulin secretion at 100 nM. |
| M8281 | 4-CMTB | 4-CMTB is a potent allosteric agonist of free fatty acid receptor 2 (FFA2). |
| M7541 | TUG-770 | Tug-770 is a potent, selective, orally active GPR40/FFA1 agonist with an EC50 of 6 nM against human FFA1. Tug-770 has higher selectivity to FFA1 than FFA2, FFA3, FFA4, PPARγ, other receptors, transporters and enzymes. |
| M6985 | Monomethyl fumarate | MMF is a activator of Nrf2 pathway; primary metabolite of DMF. |
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