Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M10562 | GPR81 agonist 1 | GPR81 agonist 1 is a potent and highly selective GPR81 agonist, with EC50 values of 58 nM and 50 nM for human and mouse GPR81, respectively. |
| M2020 | GW9508 | GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 has anti-inflammatory and anti-atherosclerotic activities. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. |
| M56203 | GPR84 antagonist 8 | GPR84 antagonist 8 is a selective GPR84 antagonist. |
| M56202 | ML191 | ML-191 is an antagonist of GPR55. |
| M56201 | CID1172084 | CID1172084 is a selective GPR55 agonist (EC50=0.16 μM). |
| M56200 | ML 145 | ML 145 is a selective and competitive human GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM. |
| M56199 | PSN 375963 hydrochloride | PSN 375963 hydrochloride is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. |
| M56189 | SAE-14 | SAE-14 is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. |
| M55551 | CID 2745687 | CID 2745687 is a specific, reversible and competitive GPR35 antagonist with a Ki of 12.8 nM. |
| M54438 | [Ala17]-MCH | [Ala17]-MCH, a MCH analogue, is a selective ligand for MCHR1 (Ki=0.16 nM) over MCHR2 (Ki=34 nM). |
| M54286 | BigLEN(rat) | BigLEN(rat) is a potent GPR171 agonist with an EC50 of 1.6 nM. |
| M53855 | BigLEN(mouse) | BigLEN(mouse) is a potent and selective agonist of orphan G protein-coupled receptor 171 (GPR171), with a Kd of ∼0.5 nM. |
| M53099 | Neuropeptide EI, rat | Neuropeptide EI, rat displays functional melanin concentrating hormone (MCH)-antagonist and melanocyte-stimulating hormone (MSH) agonist activity in different behavioral paradigms. |
| M53098 | (Phe13, Tyr19)-MCH (human, mouse, rat) | (Phe13,Tyr19)-MCH (human, mouse, rat) is a potent SLC-1 and S643b receptor ligand. |
| M53097 | Melanin Concentrating Hormone, salmon | Melanin Concentrating Hormone, salmon is a 19-amino-acid neuropeptide initially identified in the pituitary gland of teleost fish, which regulates food intake, energy balance, sleep state, and the cardiovascular system. |
| M53096 | MCH(human, mouse, rat) | MCH (human, mouse, rat) is a potent peptide agonist of MCH-R and exhibits binding IC50 values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. |
| M53095 | Ac-hMCH(6-16)-NH2 | Ac-hMCH(6-16)-NH2 binds to and activates equally well both human MCH receptors present in the brain (non-selective agonist), with IC50 values of 0.16 nM and 2.7 nM for MCH-1R and MCH-2R. |
| M49639 | ML192 | ML192 is a selective ligand antagonist of GPR55. |
| M49445 | BAY-3178275 | BAY-3178275 is an antagonist targeting GPR84 for studies related to diabetic neuropathic pain. |
| M45123 | GSK256073 | GSK256073 is a potent, selective, orally active GPR109A agonist and a potent and persistent HCA2 agonist with a pEC50 of 7.5 (Human HCA2). In addition, GSK256073 significantly improves glucose homeostasis by inhibiting lipid degradation and has potential for the study of type 2 diabetes mellitus (T2DM) and dyslipidemia. |
| M45110 | GSK4381406 | GSK4381406 is a first-in-class, orally active GPR35 agonist for studies related to inflammatory bowel disease (IBD). |
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