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AMG 837 is a potent, orally bioavailable GPR40 agonist with EC50 of 14 nM.
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Source | Physiol Rep (2015). Figure 3. AMG-837 |
| Method | Hormone measurement | |
| Cell Lines | rat small intestine | |
| Concentrations | 10 μmol/L | |
| Incubation Time | - | |
| Results | Intergroup comparisons between LA, TAK-875, AMG 837, and DMSO stimulations showed that only the GLP-1 response induced by vascular AMG 837 was significantly different from the vehicle control |
| Molecular Weight | 438.44 |
| Formula | C26H21F3O3 |
| CAS Number | 865231-46-5 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Jonathan B Houze, et al. AMG 837: a potent, orally bioavailable GPR40 agonist
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