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AMG-837

Cat. No. M2384

All AbMole products are for research use only, cannot be used for human consumption.

AMG-837 Structure
Size Price Availability Quantity
5mg USD 140  USD140 In stock
10mg USD 220  USD220 In stock
25mg USD 450  USD450 In stock
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Quality Control & Documentation
Biological Activity

AMG 837 is a potent, orally bioavailable GPR40 agonist with EC50 of 14 nM.

Customer Product Validations & Biological Datas
Source Physiol Rep (2015). Figure 3. AMG-837
Method Hormone measurement
Cell Lines rat small intestine
Concentrations 10 μmol/L
Incubation Time -
Results Intergroup comparisons between LA, TAK-875, AMG 837, and DMSO stimulations showed that only the GLP-1 response induced by vascular AMG 837 was significantly different from the vehicle control
Chemical Information
Molecular Weight 438.44
Formula C26H21F3O3
CAS Number 865231-46-5
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Xihao Chang, et al. Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation

[2] Sameer Mohammad. GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus: Benefits and Challenges

[3] Jonathan B Houze, et al. AMG 837: a potent, orally bioavailable GPR40 agonist

[4] Daniel C-H Lin, et al. AMG 837: a novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents

[5] Ryo Yazaki, et al. Enantioselective synthesis of a GPR40 agonist AMG 837 via catalytic asymmetric conjugate addition of terminal alkyne to α,β-unsaturated thioamide

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Keywords: AMG-837 supplier, GPR/FFAR, inhibitors, activators

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