About 5 results found for searched term "AMG-837" (0.052 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2384 | AMG-837 | GPR/FFAR |
| AMG 837 is a potent, orally bioavailable GPR40 agonist with EC50 of 14 nM. | ||
| M6435 | AMG 837 hemicalcium salt | Others |
| AMG 837 hemicalcium salt is a potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist. | ||
| M28079 | AMG 837 calcium hydrate | GPR/FFAR |
| AMG 837 calcium hydrate is a potent, orally bioavailable and partial agonist of GPR40/FFA1. AMG 837 calcium hydrate inhibits specific [3H]AMG 837 binding at the human FFA1 receptor with a pIC50 of 8.13. AMG 837 calcium hydrate could enhance insulin secretion and lower glucose levels in rodents. | ||
| M28760 | AMG8379 | Sodium Channel |
| AMG8379 is a potent, orally active and selective sulfonamide antagonist of the voltage-gated sodium channel NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively. AMG8379 potently and reversibly blocks endogenous Tetrodotoxin (TTX)-sensitive sodium channels in dorsal root ganglia (DRG) neurons with an IC50 of 3.1 nM. | ||
| M30741 | AMG 837 sodium salt | GPR/FFAR |
| AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. | ||
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