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AMG 837 hemicalcium salt is a potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist (EC50 values are 13.5, 22.6 and 31.7 nM at human, mouse and rat receptors, respectively). Interacts allosterically with full FFA1 agonist Docosahexaenoic acid. Potentiates glucose-dependent stimulation of insulin in vivo. Antidiabetic.
| Molecular Weight | 457.47 |
| Formula | C26H20F3O3.½Ca |
| CAS Number | 1291087-14-3 |
| Solubility (25°C) | DMSO 45.75 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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