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AMG 837 calcium hydrate is a potent, orally bioavailable and partial agonist of GPR40/FFA1. AMG 837 calcium hydrate inhibits specific [3H]AMG 837 binding at the human FFA1 receptor with a pIC50 of 8.13. AMG 837 calcium hydrate could enhance insulin secretion and lower glucose levels in rodents.
| Molecular Weight | 455.45 |
| Formula | C26H21F3O3.1/2Ca.H2O |
| CAS Number | 1259389-38-2 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 42 mg/mL |
| Storage | 4°C, dry, sealed |
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