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AZD1981

Cat. No. M2418

All AbMole products are for research use only, cannot be used for human consumption.

AZD1981 Structure
Size Price Availability
5mg USD 50  USD50 Out of stock
10mg USD 95  USD95 Out of stock
50mg USD 390  USD390 Out of stock
100mg USD 580  USD580 Out of stock
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Quality Control & Documentation
Biological Activity

AZD1981 is a potent, selective CRTh2 (DP2) receptor antagonist with IC50 of 4 nM, showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. AZD1981 blocks DP2-mediated shape change in human eosinophils and basophils in blood, as well as DP2-mediated chemotaxis of human Th2 cells and eosinophils. what's more, AZD1981 also blocks the binding of [3H]PGD2 to mouse, rat, guinea pig, rabbit and dog recombinant DP2. In guinea pig hind limb model, AZD1981 (100 nM) completely inhibits DK-PGD2-induced eosinophil mobilization.

Chemical Information
Molecular Weight 388.87
Formula C19H17ClN2O3S
CAS Number 802904-66-1
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Br J Pharmacol,et al. Br J Pharmacol. Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma.

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