Free shipping on all orders over $ 500

OC000459

Cat. No. M2091

All AbMole products are for research use only, cannot be used for human consumption.

OC000459 Structure
Synonym:

Timapiprant

Size Price Availability Quantity
5mg USD 60  USD60 In stock
10mg USD 95  USD95 In stock
25mg USD 190  USD190 In stock
50mg USD 300  USD300 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

OC000459 is a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils. OC000459 inhibited chemotaxis (IC50 = 0.028 μM) of human Th2 lymphocytes and cytokine production (IC50 = 0.019 μM) by human Th2 lymphocytes. OC000459 also inhibited the activation of Th2 cells and eosinophils in response to supernatants from IgE/anti-IgE-activated human mast cells. OC000459 was shown to inhibit blood eosinophilia in rats induced by 13,14-dihydro-15-keto PGD2 (Item No. 12610) (ED50 = 0.04 mg/kg) and airway eosinophilia in guinea pigs in response to an aerosol of 13,14-dihydro-15-keto PGD2 (ED50 = 0.01 mg/kg). OC000459 treatment inhibited LAR and post-allergen increase in sputum eosinophils and led to a significant and persistent reduction in the symptoms of rhinoconjunctivitis.

Chemical Information
Molecular Weight 348.37
Formula C21H17FN2O2
CAS Number 851723-84-7
Solubility (25°C) DMSO 4 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Horak F, et al. Allergy. The CRTH2 antagonist OC000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo-controlled, double-blind trial.

[2] Singh D, et al. Eur Respir J. Inhibition of the asthmatic allergen challenge response by the CRTH2 antagonist OC000459.

[3] Pettipher R, et al. J Pharmacol Exp Ther. Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils.

[4] Barnes N, et al. Clin Exp Allergy. A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma.

Related GPR/FFAR Products
GPR84 antagonist 8 

GPR84 antagonist 8 is a selective GPR84 antagonist.
ML191

ML-191 is an antagonist of GPR55.
CID1172084 

CID1172084 is a selective GPR55 agonist (EC50=0.16 μM).
ML 145 

ML 145 is a selective and competitive human GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM.
PSN 375963 hydrochloride 

PSN 375963 hydrochloride is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively.
  Catalog
Abmole Inhibitor Catalog




Keywords: OC000459, Timapiprant supplier, GPR/FFAR, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.