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MCH TFA (human, mouse, rat)

Cat. No. M10469
MCH TFA (human, mouse, rat) Structure
Size Price Availability Quantity
5mg USD 347  USD347 In stock
10mg USD 585  USD585 In stock
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Quality Control & Documentation
Biological Activity

MCH TFA (human, mouse, rat) is a potent peptide agonist of MCH-R and exhibits binding IC50 values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. MCH TFA (human, mouse, rat) is a highly sensitive to MCH-2R in a CHO cell line and monitoring mobilization of intracellular calcium with FLIPR, exhibits functional activation EC50 values of 3.9 nM and 0.1nM for human MCH-1R and MCH-2R, respectively.

Chemical Information
Molecular Weight 2500.86
Formula C107H161F3N30O28S4
CAS Number 128315-56-0 (free base)
Solubility (25°C) DMSO 90 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] A W Sailer, et al. Proc Natl Acad Sci U S A. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R

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