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TUG-424 is a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC50 of 32 nM. TUG-424 significantly enhanced glucose-stimulated insulin secretion in a rat beta-cell line already at 100 nM and from isolated mouse islets through FFA1.
| Molecular Weight | 264.32 |
| Formula | C18H16O2 |
| CAS Number | 1082058-99-8 |
| Solubility (25°C) | DMSO ≥10 mg/mL |
| Storage | -20°C |
[3] Ellen Hagesaether, et al. Mucus can change the permeation rank order of drug candidates
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