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TUG-891 is a potent and selective agonist of the long chain free fatty acid (LCFA) receptor 4 (FFAR4/GPR120), which demonstrates both potential opportunity and possible challenges to therapeutic agonism. TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also resulted in rapid phosphorylation and internalization of the receptor. TUG-891 was also a potent agonist of mouse FFA4, but it showed only limited selectivity over mouse FFA1.
| Molecular Weight | 364.41 |
| Formula | C23H21FO3 |
| CAS Number | 1374516-07-0 |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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