Free shipping on all orders over $ 500


Cat. No. M9494
AF64394 Structure


Size Price Availability Quantity
5mg USD 155  USD155 In stock
10mg USD 250  USD250 In stock
25mg USD 525  USD525 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

AF64394 is a selective GPR3 inverse agonist with a pIC50 of 7.3.

Chemical Information
Molecular Weight 393.87
Formula C21H20ClN5O
CAS Number 1637300-25-4
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Jensen T, et al. Bioorg Med Chem Lett. The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function.

Related GPR/FFAR Products

(±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line.

BAM(8-22) TFA 

BAM(8-22) TFA, a proteolytically cleaved product of proenkephalin A, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1, and induces scratching in mice in an Mrgpr-dependent manner.

GPR35 agonist 4 

GPR35 agonist 4 (compound 10) is a potent GPR35 agonist with an pEC50 of 5.86. GPR35 agonist 4 shows high potency human and rat GPR35. Mutation of arginine 3.36 eliminates agonist function of GPR35 agonist 4.

AMG 837 sodium salt 

AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.


GSK299115A is a G Protein-coupled Receptor Kinase (GRK) and PKA inhibitor.

Abmole Inhibitor Catalog

Keywords: AF64394, AF-64394 supplier, GPR/FFAR, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.