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AF64394

Cat. No. M9494
AF64394 Structure
Synonym:

AF-64394

Size Price Availability Quantity
5mg USD 155  USD155 In stock
10mg USD 250  USD250 In stock
25mg USD 525  USD525 In stock
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Quality Control & Documentation
Biological Activity

AF64394 is a selective GPR3 inverse agonist with a pIC50 of 7.3.

Chemical Information
Molecular Weight 393.87
Formula C21H20ClN5O
CAS Number 1637300-25-4
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jensen T, et al. Bioorg Med Chem Lett. The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function.

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  Catalog
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Keywords: AF64394, AF-64394 supplier, GPR/FFAR, inhibitors, activators


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