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CID1231538

Cat. No. M55197
CID1231538 Structure
Size Price Availability Quantity
5mg USD 170  USD170 In stock
10mg USD 260  USD260 In stock
25mg USD 500  USD500 In stock
50mg USD 800  USD800 In stock
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Quality Control & Documentation
Biological Activity

CID1231538 is a potent GPR35 antagonist, with IC50 of 0.55 μM. CID1231538 is a benzothiazole analogue. GPR35 is a G protein-coupled receptor. GPR35 has gained special consideration as a result of its association with many diseases including type-2 diabetes, nociceptive pain, inflammation, mild mental retardation syndrome, metabolic disorders, and gastric cancer.

Chemical Information
Molecular Weight 524.05
Formula C26H22ClN3O3S2
CAS Number 354126-20-8
Solubility (25°C) DMSO 50 mg/mL
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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  Catalog
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