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ML204

Cat. No. M5205
ML204 Structure
Size Price Availability Quantity
5mg USD 55  USD55 In stock
10mg USD 88  USD88 In stock
50mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.

In vitro: ML204 inhibited TRPC4β-mediated intracellular Ca(2+) rise with an IC(50) value of 0.96 μm and exhibited 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation.

Chemical Information
Molecular Weight 226.32
Formula C15H18N2
CAS Number 5465-86-1
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Miller M, et al. J Biol Chem. Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.

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Keywords: ML204 supplier, Calcium Channel, inhibitors, activators


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