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EIPA

Cat. No. M6705
EIPA Structure
Synonym:

L593754; MH 12-43; Ethylisopropylamiloride

Size Price Availability Quantity
5mg USD 100  USD100 In stock
10mg USD 150  USD150 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

EIPA is a tRPP3 channel inhibitor (IC50 = 10.5 μM). EIPA inhibits the Na+/H+ exchanger (NHE). Derivative of amiloride.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 299.76
Formula C11H18ClN7O
CAS Number 1154-25-2
Purity >98%
Solubility 1eq. HCl 14.99 mg/mL
Storage at -20°C
References

[1] Hemstapat, et al. Mol Pharmacol. A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: EIPA, L593754; MH 12-43; Ethylisopropylamiloride supplier, TRP Channel, inhibitors

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