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ML SA1

Cat. No. M6983
ML SA1 Structure
Size Price Availability Quantity
10mg USD 160  USD160 In stock
25mg USD 360  USD360 In stock
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Quality Control
Biological Activity

ML SA1 is a activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca2+ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 362.42
Formula C22H22N2O3
CAS Number 332382-54-4
Purity 98.07%
Solubility DMSO 5.25 mg/mL
Storage at -20°C
References

[1] Yang Wang, et al. Oxid Med Cell Longev. Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia

[2] Yadav, et al. J Pharmacol Exp Ther. Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists differentially regulate 5-HT2A receptor protein level in vivo.

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Keywords: ML SA1 supplier, TRP Channel, inhibitors

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