About 33 results found for searched term "SSI-4" (0.058 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3173 | Potassium canrenoate | Mineralocorticoid Receptor |
| Aldadiene potassium, SC-14266 | ||
| Canrenoate potassium is a predrug for the release of Canrenone and an effective antagonist of competitive salt ocorticoid receptor. As a diuretic, Canrenoate potassium is used in the study of hypertension. | ||
| M42615 | SSI-4 | Stearoyl-CoA Desaturase |
| SSI-4 is an inhibitor of Stearoyl CoA desaturase 1 (SCD1) , which can be modified with 11C, used as a ligand to in vivo small animal PET/CT imaging of SCD1. | ||
| M57570 | potassium 1,2-naphthoquinone-4-sulphonate | Others |
| potassium 1,2-naphthoquinone-4-sulphonate | ||
| M1749 | Gefitinib | EGFR/HER2 |
| ZD-1839, Iressa | ||
| Gefitinib (ZD1839) is an EGFR tyrosine kinase and Akt phosphorylation inhibitor. Gefitinib significantly down-regulates CD47 expression and increases DC phagocytosis in non-small cell lung cancer cells such as PC9, H1437 and H1573. Gefitinib combined with CD47 antibody can enhance the phagocytosis of macrophages. | ||
| M1917 | Mozavaptan | Vasopressin Receptor |
| OPC-31260 | ||
| Mozavaptan (OPC-31260) is a benzazepine derivative and a potent, selective, competitive and orally active vasopressin V2 receptor antagonist with an IC50 of 14 nM. Mozavaptan shows ~85-fold selectivity for V2 receptor over V1 receptor (IC50 of 1.2 μM), and can antagonize the antidiuretic action of arginine vasopressin (AVP) in vivo. | ||
| M1921 | Mizoribine | DNA/RNA Synthesis |
| Bredinin | ||
| Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM. Mizoribine inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively. | ||
| M2071 | ONX-0914 | Proteasome |
| PR-957 | ||
| Onx-0914 (PR-957) is a selective inhibitor of low molecular weight polypeptide 7 (LMP7), a chymotrypsin subunit of the immune proteasome. Onx-0914 blocks cytokine production and reduces the progression of experimental arthritis. Onx-0914 is a non-competitive irreversible inhibitor of mycobacterium proteasome (Ki=5.2 μM). Onx-0914 activates latent HIV-1 through HF-1-mediated p-TEFb activation. | ||
| M2167 | (+)-JQ1 | Epigenetic Reader Domain |
| JQ1 | ||
| (+)-JQ1 is a BET bromodomain inhibitor that acts on BRD4(2) with an IC50 of 33 nM and binds to all bromodomain domains in the BET family, but not to bromodomain domains outside the BET family. JQ1 down-regulates CD47 expression through a C-MYC-mediated pathway, and JQ1 down-regulates CD47 expression through a C-MYC-mediated pathway. | ||
| M2281 | Exemestane | Others |
| Aromasin | ||
| Exemestane, a kind of Aromatase (CYP19A1) inhibitor, more profoundly inhibited the cell proliferation of KKU-213 cells highly expressing CYP19A1, and inhibited Aromatase in human placenta and rat ovary, with IC50 of 30 nM and 40 nM, respectively. | ||
| M2328 | Pirfenidone | TGF-beta/Smad |
| AMR69; S-7701 | ||
| Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells. Pirfenidone (AMR69) attenuates CCL2 and CCL12 production in fibrocyte cells. | ||
| M2813 | LGX818 | Raf |
| Encorafenib | ||
| LGX818 is a highly potent RAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing B-RAF(V600E) with EC50 of 4 nM. | ||
| M2896 | OAC1 | Others |
| OAC1 (Oct4-activating compound 1) is a potent Oct4 activator that activates both the Oct4 and Nanog promoters, promotes induced multifunctional stem cell (iPSC) formation, and activates OCT4 through upregulation of HOXB4 expression.Additionally, OAC1 increases the transcription of the Oct4-Nanog-Sox2 triplet and TET1 and promotes cell reprogramming by increasing efficiency and shortening reprogramming time. and TET1 transcription, and may promote cell reprogramming by increasing efficiency and shortening reprogramming time. | ||
| M3001 | SC144 | IL Receptor/Related |
| SC144 is the first oral active GP130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, eliminates Stat3 phosphorylation and nuclear translocation, and further inhibits downstream target gene expression. SC144 inhibited signal transduction induced by GP130 ligand. SC144 induces apoptosis of human ovarian cancer cells. | ||
| M3399 | Gliclazide | Potassium Channel |
| S1702; SE1702 | ||
| Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. | ||
| M3411 | Sotalol | Adrenergic Receptor |
| Sotalol is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM. | ||
| M3412 | Propafenone hydrochloride | Sodium Channel |
| Propafenone HCl is a sodium-channel blocker that also has a high affinity for β-receptors (IC50 = 32 nM). It blocks transient outward potassium current (Ito) and sustained delayed rectifier K+ current (Isus) with IC50 values of 4.9 μM and 8.6 μM, respectively.In addition, Propafenone inhibits the proliferation of esophageal cancer by inducing mitochondrial dysfunction and apoptosis. | ||
| M3794 | Tomeglovir | Anti-infection |
| BAY 38-4766 | ||
| Tomeglovir is a novel nonnucleosidic inhibitor of human cytomegalovirus replication. Tomeglovir is a potent anti-CMV agent, inhibiting processing of viral DNA-concatemers, with IC50s of 0.34 μM and 0.039 μM for HCMV and MCMV. | ||
| M3983 | Puerarin | 5-HT Receptor |
| Puerarin is a 5-HT2C receptor antagonist. Puerarin inhibits the expression of LPS-induced iNOS, COX-2 and CRP proteins and also suppresses their mRNAs from RT-PCR experiments in RAW264.7 cells. | ||
| M4030 | Crassicauline-A | Others |
| Crassicaulin A | ||
| Crassicauline A (Crassicaulin A) is A bioactive alkaloid in aconite roots. Crassicauline A (Crassicaulin A) had antifeedant activity against the adult Raptor, and its EC50 value was 1134.5 PPM. | ||
| M4075 | Ginsenoside-Rd | NF-κB |
| Gypenoside VIII | ||
| Ginsenoside Rd inhibited NF-κB transcriptional activity induced by TNFα with IC50 of 12.05±0.82 μM. Ginsenoside Rd inhibited the expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibited CYP2D6, CYP1A2, CYP3A4 and CYP2C9 with IC50 of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM and 85.1±9.1 μM, respectively. | ||
| M4085 | Ginsenoside-F3 | IL Receptor/Related |
| Ginsenoside F3, a saponin extracted from Panax ginseng leaves, exerts immune-enhancing activity by regulating the production and expression of il-2 (IFN-γ) and IL-4 and IL-10. | ||
| M4204 | Baohuoside-I | CXCR |
| Icariin-II; Icariside-II | ||
| Baohuoside I is a flavonoid obtained from Epimedium Korean. As an inhibitor of CXCR4, Baohuoside I can inhibit the expression of CXCR4 and induce apoptosis, showing antitumor activity. | ||
| M4422 | Sennidin-A | Anti-infection |
| Sennidin A was isolated from Cassia Angustifolia and inhibited HCV NS3 helicase with an IC50 value of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4). Sennidin A stimulates glucose incorporation. | ||
| M4423 | Sennidin-B | Anti-infection |
| Sennidin B can be isolated from Cassia Angustifolia and is an isomer of Sennidin A with lower activity than Sennidin A. Sennidin A inhibited HCV NS3 helicase with an IC50 value of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4). Sennidin A stimulates glucose incorporation. | ||
| M4496 | Linderalactone | Apoptosis |
| Linderalactone is an important sesquiterpene lactone isolated from Radix Linderae. Linderalactone inhibits cancer cell growth by regulating the expression of apoptosis-related proteins and inhibiting the JAK/STAT signaling pathway. Linderalactone also inhibited the proliferation of lung cancer A-549 cells with an IC50 value of 15 µM. | ||
| M4510 | Madecassic-acid | NO Synthase |
| Madecassic acid was isolated from Centella asiatica (umbelliferae). Madecassic acid showed inhibition of iNOS, COX-2, TNF-α, IL-1beta and IL-6, and had anti-inflammatory effect by down-regulation of NF-κB activation in RAW 264.7 macrophages. | ||
| M4621 | Garcinone-C | ATM/ATR |
| Garcinone C is a xanthone derivative, a natural compound extracted from Garcinia oblongifolia Champ. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while effectively inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, CDC2, Stat3 and CDK7. | ||
| M4710 | Shionone | NLR |
| Shionone, isolated from Aster Tataricus, is a triterpenoid compound with antitussive and anti-inflammatory activities. Shionone has a unique six-membered four-ring framework and a 3-oxygen-4-monomethyl structure. | ||
| M4729 | α-Cyperone | Metabolite/Endogenous Metabolite |
| α-Cyperone; (+)-α-Cyperone | ||
| Alpha-cyperone (α -cyperone) is associated with down-regulated expression of COX-2, IL-6, NCK-2, Cdc42, and Rac1, thereby reducing the inflammatory response.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M4755 | Apioside | NO Synthase |
| Apiin is one of the main components of Apium graveolens leaves and has anti-inflammatory properties. Apiin could inhibit nitrite (NO) production in vitro (IC50 = 0.08 mg/mL) and iNOS expression in LPS-activated J774.A1 cells (IC50 = 0.049 mg/mL). | ||
| M4838 | TAK-242 (Resatorvid) | TLR |
| Resatorvid; CLI-095 | ||
| Resatorvid (TAK-242) is a selective TLR4 signaling inhibitor. Resatorvid inhibited the production of NO, TNF-α and IL-6 with IC50 values of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid down-regulates the expression of MyD88 and TRIF signaling molecules downstream of TLR4. Resatorvid inhibits autophagy and plays a key role in a variety of inflammatory diseases. | ||
| M4849 | 7-Aminoactinomycin D | Nucleic Acid Staining |
| 7-AAD | ||
| 7-aminoactinomycin D (7-aad) can bind to DNA, and the maximum excitation/emission wavelength is 546nm/647 nm. The best excitation laser is 561nm or 488nm. It gives red fluorescence and is often used to observe the nucleus and nucleic acid. Store in freezer (-5 to -30°C) away from light. The solvent was DMSO. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M5106 | DAPI dihydrochloride | Fluorescent Dye |
| 4',6-Diamidino-2-phenylindole dihydrochloride | ||
| DAPI dihydrochloride is A fluorescent dye that binds DNA rich in a-T sequences. The maximum excitation/emission wavelength is 358nm/461 nm, and the blue fluorescence is often used to observe the nucleus and nucleic acid. Store at room temperature away from light. | ||
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