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OAC1

Cat. No. M2896

All AbMole products are for research use only, cannot be used for human consumption.

OAC1 Structure
Size Price Availability Quantity
5mg USD 80  USD80 In stock
10mg USD 120  USD120 In stock
50mg USD 410  USD410 In stock
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Quality Control & Documentation
Biological Activity

OAC1 (Oct4-activating compound 1) enhances recoding efficiency. 1 μM OAC1 enhances reprogramming efficiency by activating the luciferase reporter gene driven by the Oct4 and Nanog promoters. In addition, OAC1 acted on mouse embryonic fibroblasts (MEFs) treated with four reprogramming factors (Oct4, Sox2, c-Myc, and Klf4) to enhance the reprogramming efficiency of pluripotent stem cells (iPSCs) and accelerate the reprogramming process. The iPSC colonies derived from treatment with OAC1 together with the four reprogramming factors exhibited typical ESC morphology, gene expression patterns, and developmental potential.

Chemical Information
Molecular Weight 237.26
Formula C14H11N3O
CAS Number 300586-90-7
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Mai Xu, et al. Efficient screening of novel adsorbents for coalbed methane recovery

[2] Mengmeng Jiang, et al. Maintenance of human haematopoietic stem and progenitor cells in vitro using a chemical cocktail

[3] X Huang, et al. Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression

[4] Felicia Tsang, et al. Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae

[5] Wendong Li, et al. Identification of Oct4-activating compounds that enhance reprogramming efficiency

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Keywords: OAC1 supplier, inhibitors, activators

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