OAC1 (Oct4-activating compound 1) enhances recoding efficiency. 1 μM OAC1 enhances reprogramming efficiency by activating the luciferase reporter gene driven by the Oct4 and Nanog promoters. In addition, OAC1 acted on mouse embryonic fibroblasts (MEFs) treated with four reprogramming factors (Oct4, Sox2, c-Myc, and Klf4) to enhance the reprogramming efficiency of pluripotent stem cells (iPSCs) and accelerate the reprogramming process. The iPSC colonies derived from treatment with OAC1 together with the four reprogramming factors exhibited typical ESC morphology, gene expression patterns, and developmental potential.
| Molecular Weight | 237.26 |
| Formula | C14H11N3O |
| CAS Number | 300586-90-7 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Mai Xu, et al. Efficient screening of novel adsorbents for coalbed methane recovery
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