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Garcinone-C

Cat. No. M4621
Garcinone-C Structure
Size Price Availability Quantity
20mg USD 750  USD750 In stock
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Quality Control & Documentation
Biological Activity

Garcinone C is a xanthone derivative, a natural compound extracted from Garcinia oblongifolia Champ. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while effectively inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, CDC2, Stat3 and CDK7.

Chemical Information
CAS Number 76996-27-5
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mirielle C Nauman, et al. The purple mangosteen (Garcinia mangostana): Defining the anticancer potential of selected xanthones

[2] Jing Chen, et al. Garcinone C suppresses colon tumorigenesis through the Gli1-dependent hedgehog signaling pathway

[3] Xican Li, et al. 2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide Radical (PTIO•) Trapping Activity and Mechanisms of 16 Phenolic Xanthones

[4] Yudui Xia, et al. Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E‑BP1 in nasopharyngeal carcinoma cells

[5] K Y Khaw, et al. Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies

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