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Madecassic-acid

Cat. No. M4510

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Madecassic-acid Structure
Size Price Availability Quantity
20mg USD 100  USD100 In stock
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Quality Control & Documentation
Biological Activity

Madecassic acid was isolated from Centella asiatica (umbelliferae). Madecassic acid showed inhibition of iNOS, COX-2, TNF-α, IL-1beta and IL-6, and had anti-inflammatory effect by down-regulation of NF-κB activation in RAW 264.7 macrophages.

Chemical Information
Molecular Weight 504.70
Formula C30H48O6
CAS Number 18449-41-7
Form Solid
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage 4°C, protect from light, dry, sealed
References

[1] Sonia Siddiqui, et al. Madecassic Acid Reduces Fast Transient Potassium Channels and Promotes Neurite Elongation in Hippocampal CA1 Neurons

[2] Ana S C Valdeira, et al. Madecassic Acid Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxic Evaluation

[3] Xiaotian Xu, et al. Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway

[4] Hua Zhang, et al. Madecassic acid inhibits the mouse colon cancer growth by inducing apoptosis and immunomodulation

[5] Wiesława Bylka, et al. Centella asiatica in dermatology: an overview

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Keywords: Madecassic-acid supplier, NO Synthase, inhibitors, activators

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