Crocin II, isolated from the fruit of Gardenia jasminoides, has antioxidant, anticancer and antidepressant activities. Crocin II inhibited NO production with IC50 value of 31.1 μM. Crocin II inhibited the expression of iNOS and COX-2 protein and M-RNA.
| Molecular Weight | 814.82 |
| Formula | C38H54O19 |
| CAS Number | 55750-84-0 |
| Form | Solid |
| Solubility (25°C) | Water Ethanol |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related NO Synthase Products |
|---|
| 6-Methoxynaringenin
6-Methoxynaringenin is an aerial part of Scutellaria barbata D. Don (Lamiaceae) and inhibits NO production efficiently with an IC50 value of 25.8 μM. |
| Camstatin
Camstatin, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal nitric oxide (NO) synthase. |
| N'-Nitro-D-arginine
N'-Nitro-D-arginine, a nitric oxide synthesis inhibitor, also is a vasodilator that relaxes the smooth muscles and increases blood flow to the penis, improving erections. |
| DETA NONOate
DETA NONOate is an exogenous nitric oxide (NO) donor that activates inward currents in cultured rat cerebellar granule cells and increases cGMP production in vascular smooth muscle cells. |
| Cis-N-Feruloyltyramine
N-cis-Feruloyl tyramine (cis-N-(4-Hydroxyphenethyl) ferulamide) is a natural phenolic compound, exhibits modest inhibitory activity on LPS-activated NO production in RAW 264.7 cells. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
