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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M2818 | L-NAME hydrochloride | L-NAME hydrochloride is a nonselective inhibitor of nitric oxide synthetases (NOS) for nNOS (bovine), eNOS (human), and iNOS (murine), with Ki of 15 nM, 39 nM and 4.4 μM, respectively. |
| M10446 | 1400W dihydrochloride | 1400W dihydrochloride is a potent and selective inhibitor of human inducible NO synthase with Ki values of 7 nM. |
| M21413 | Inflexuside B | Inflexuside B, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages |
| M20791 | Amcinonide | Amcinonide (Cyclocort, CL-34699) is an inhibitor of nitric oxide (NO) release from activated microglia with IC50 of 3.38 nM. |
| M20781 | Bendazol | Bendazol (2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan) is a hypotensive drug that enhances NO synthase activity in renal glomeruli and collecting tubules. Bendazol inhibits the progression of form-deprivation myopia (FDM) and suppresses the upregulation of HIF-1α. |
| M14101 | Syzalterin | Syzalterin is an inhibitor of NO production with an IC50 of 1.87 μg/mL. |
| M14100 | L-NIO dihydrochloride | L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively. |
| M14099 | L-NIL | L-NIL is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS. |
| M14098 | GW274150 phosphate | GW274150 phosphate is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). |
| M14097 | Asperuloside | Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways. |
| M10556 | L-NMMA acetate | L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms, with Ki values of approximately 0.18, 0.4, and 6 µM for nNOS (rat), eNOS (human), and iNOS (mouse), respectively. |
| M10446 | 1400W dihydrochloride | 1400W dihydrochloride is a potent and selective inhibitor of human inducible NO synthase with Ki values of 7 nM. |
| M10320 | Chondroitin sulfate | Chondroitin sulfate is a class of sulfated glycosaminoglycans that are linear polysaccharides consisting of repeating disaccharide units composed of uronic acid and N-acetylhexosamine, which has been widely used in the treatment of osteoarthritis. |
| M10049 | GSK2795039 | GSK2795039 is the first small molecule NADPH oxidase 2 (NOX2) inhibitor, with a mean pIC50 of 6 in different cell-free assays. |
| M9588 | SNAP | SNAP is a nitrosothiol derivative, releases nitric oxide, acts as a stable inhibitor of platelet aggregation. |
| M9251 | HTHQ | HTHQ is a lipid peroxidation inhibitor potentially for the treatment of hepatic fibrosis. |
| M2818 | L-NAME hydrochloride | L-NAME hydrochloride is a nonselective inhibitor of nitric oxide synthetases (NOS) for nNOS (bovine), eNOS (human), and iNOS (murine), with Ki of 15 nM, 39 nM and 4.4 μM, respectively. |
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