| Cat.No. | Name | Information |
|---|---|---|
| M10446 | 1400W dihydrochloride | 1400W dihydrochloride is a potent and selective inhibitor of human inducible NO synthase with Ki values of 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex. |
| M58310 | FeTPPS | FeTPPS acts as a peroxynitrite scavenger and anti-nitrating agent in vivo. FeTPPS reduces nitric oxide (NO) production and apoptosis process. FeTPPS possesses evident neuroprotective effects in a experimental model of spinal cord damage. |
| M56380 | GW274150 | GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). |
| M55388 | 2-Iminobiotin | 2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5μM for murine iNOS and rat n-cNOS, respectively. 2-Iminobiotin superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage. |
| M55387 | 2-Iminobiotin hydrobromide | 2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5 μM for murine iNOS and rat n-cNOS, respectively. 2-Iminobiotin hydrobromide superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage. |
| M54740 | 6-Methoxynaringenin | 6-Methoxynaringenin is an aerial part of Scutellaria barbata D. Don (Lamiaceae) and inhibits NO production efficiently with an IC50 value of 25.8 μM. |
| M49928 | DETA NONOate | DETA NONOate is an exogenous nitric oxide (NO) donor that activates inward currents in cultured rat cerebellar granule cells and increases cGMP production in vascular smooth muscle cells. |
| M38994 | Shizukaol B | Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression. |
| M38993 | Cauloside D | Cauloside D is a triterpene glycoside isolated from Caulophyllum robustum Max. Cauloside D exerts anti-inflammatory effects through the inhibition of expression of iNOS and proinflammatory cytokines. |
| M22492 | MAHMA NONOate | MAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP. |
| M20791 | Amcinonide | Amcinonide (Cyclocort, CL-34699) is an inhibitor of nitric oxide (NO) release from activated microglia with IC50 of 3.38 nM. |
| M18586 | Ciwujianoside C3 | Ciwujianoside C3 is an orally active and brain penetrated compound, which is isolated the leaves of Acanthopanax henryi Harms. Ciwujianoside C3 has anti-inflammatory effect and can reinforces object recognition memory. |
| M14097 | Asperuloside | Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways. |
| M11376 | 2,4-Diamino-6-hydroxypyrimidine | 2, 4-diamino-6-hydroxypyrimidine is a specific inhibitor of GTP cyclohydrolase I, a rate-limiting enzyme involved in de novo protein synthesis. 2, 4-diamino-6-hydroxypyrimidine can block the synthesis of Tetrahydrobiopterin (BH4) and inhibit the production of NO. |
| M10999 | Luteolin 5-O-glucoside | Luteolin 5-O-glucoside from Cirsium maackii has anti-inflammatory activity. Luteolin 5-O-glucoside inhibits LPS-induced NO production and t-BHP-induced ROS production. Luteolin 5-O-glucoside acts on macrophages and also inhibits iNOS and COX-2 expression. |
| M10926 | S-Methylisothiourea sulfate | S-Methylisothiourea sulfate is a highly effective, selective, competitive inducible nitric oxide synthase (iNOS) inhibitor. S-Methylisothiourea sulfate plays a beneficial role in rodent models of septic shock. |
| M10556 | L-NMMA acetate | L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms, with Ki values of approximately 0.18, 0.4, and 6 µM for nNOS (rat), eNOS (human), and iNOS (mouse), respectively. |
| M9588 | SNAP | SNAP (S-Nitroso-N-acetyl-DL-penicillamine) is a nitrosothiol derivative, releases nitric oxide, acts as a stable inhibitor of platelet aggregation. |
| M9251 | HTHQ | HTHQ is a lipid peroxidation inhibitor potentially for the treatment of hepatic fibrosis. |
| M7431 | TRIM | TRIM is a a potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC50 values of 28.2, 27.0 and 1057.5 μM respectively). |
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