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NOS Nitric oxide synthase

Cat.No.  Name Information
M10446 1400W dihydrochloride 1400W dihydrochloride is a potent and selective inhibitor of human inducible NO synthase with Ki values of 7 nM.
M22492 MAHMA NONOate MAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP.
M20791 Amcinonide Amcinonide (Cyclocort, CL-34699) is an inhibitor of nitric oxide (NO) release from activated microglia with IC50 of 3.38 nM.
M11376 2,4-Diamino-6-hydroxypyrimidine 2, 4-diamino-6-hydroxypyrimidine is a specific inhibitor of GTP cyclohydrolase I, a rate-limiting enzyme involved in de novo protein synthesis. 2, 4-diamino-6-hydroxypyrimidine can block the synthesis of Tetrahydrobiopterin (BH4) and inhibit the production of NO.
M10999 Luteolin 5-O-glucoside Luteolin 5-O-glucoside from Cirsium maackii has anti-inflammatory activity. Luteolin 5-O-glucoside inhibits LPS-induced NO production and t-BHP-induced ROS production. Luteolin 5-O-glucoside acts on macrophages and also inhibits iNOS and COX-2 expression.
M10926 S-Methylisothiourea sulfate S-Methylisothiourea sulfate is a highly effective, selective, competitive inducible nitric oxide synthase (iNOS) inhibitor. S-Methylisothiourea sulfate plays a beneficial role in rodent models of septic shock.
M10556 L-NMMA acetate L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms, with Ki values of approximately 0.18, 0.4, and 6 µM for nNOS (rat), eNOS (human), and iNOS (mouse), respectively.
M9588 SNAP SNAP is a nitrosothiol derivative, releases nitric oxide, acts as a stable inhibitor of platelet aggregation.
M9251 HTHQ HTHQ is a lipid peroxidation inhibitor potentially for the treatment of hepatic fibrosis.
M5408 Aminoguanidine hydrochloride Aminoguanidine hydrochloride is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone.
M5183 Kuwanon A Kuwanon A
M5154 Diphenyleneiodonium chloride Diphenyleneiodonium chloride (DPI) is an irreversible inhibitor of iNOS and eNOS with IC50 values of 50 nM and 0.3 µM, respectively.
M4755 Apioside Apiin is one of the main components of Apium graveolens leaves and has anti-inflammatory properties. Apiin could inhibit nitrite (NO) production in vitro (IC50 = 0.08 mg/mL) and iNOS expression in LPS-activated J774.A1 cells (IC50 = 0.049 mg/mL).
M4712 Irisflorentin Irisflorentin, a naturally occurring isoflavone, is an abundant active ingredient in Rhizoma Belamcandae. Irisflorentin significantly reduced the transcription and translation levels of iNOS and NO production.
M4510 Madecassic-acid Madecassic acid was isolated from Centella asiatica (umbelliferae). Madecassic acid showed inhibition of iNOS, COX-2, TNF-α, IL-1beta and IL-6, and had anti-inflammatory effect by down-regulation of NF-κB activation in RAW 264.7 macrophages.
M4500 Crocin-II Crocin II, isolated from the fruit of Gardenia jasminoides, has antioxidant, anticancer and antidepressant activities. Crocin II inhibited NO production with IC50 value of 31.1 μM. Crocin II inhibited the expression of iNOS and COX-2 protein and M-RNA.
M4390 Imperatorin Imperatorin is a potent NO synthesis inhibitor with an IC50 of 9.2 μmol and a BChE inhibitor with an IC50 of 31.4 μmol. Imperatorin is a weak agonist of TRPV1 with an EC50 of 12.6±3.2 μM.
M2357 2-Thiouracil 2-Thiouracil is a thiolated uracil derivative that is a known antihyperthyroid agent.
M38996 Kazinol B Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research.
M38995 Physalin O Physalin O is a physalin that can be isolated from Physalis angulata. Physalin O shows cytotoxicity to Hep G2 and MCF-7 cancer cells with IC50 values of 31.1 and 11.4 µM, respectively. Physalin O inhibits the production of nitric oxide (NO) and shows anti-inflammatory activities.

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