| Cat.No. | Name | Information |
|---|---|---|
| M10446 | 1400W dihydrochloride | 1400W dihydrochloride is a potent and selective inhibitor of human inducible NO synthase with Ki values of 7 nM. |
| M22492 | MAHMA NONOate | MAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP. |
| M20791 | Amcinonide | Amcinonide (Cyclocort, CL-34699) is an inhibitor of nitric oxide (NO) release from activated microglia with IC50 of 3.38 nM. |
| M11376 | 2,4-Diamino-6-hydroxypyrimidine | 2, 4-diamino-6-hydroxypyrimidine is a specific inhibitor of GTP cyclohydrolase I, a rate-limiting enzyme involved in de novo protein synthesis. 2, 4-diamino-6-hydroxypyrimidine can block the synthesis of Tetrahydrobiopterin (BH4) and inhibit the production of NO. |
| M10999 | Luteolin 5-O-glucoside | Luteolin 5-O-glucoside from Cirsium maackii has anti-inflammatory activity. Luteolin 5-O-glucoside inhibits LPS-induced NO production and t-BHP-induced ROS production. Luteolin 5-O-glucoside acts on macrophages and also inhibits iNOS and COX-2 expression. |
| M10926 | S-Methylisothiourea sulfate | S-Methylisothiourea sulfate is a highly effective, selective, competitive inducible nitric oxide synthase (iNOS) inhibitor. S-Methylisothiourea sulfate plays a beneficial role in rodent models of septic shock. |
| M10556 | L-NMMA acetate | L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms, with Ki values of approximately 0.18, 0.4, and 6 µM for nNOS (rat), eNOS (human), and iNOS (mouse), respectively. |
| M9588 | SNAP | SNAP is a nitrosothiol derivative, releases nitric oxide, acts as a stable inhibitor of platelet aggregation. |
| M9251 | HTHQ | HTHQ is a lipid peroxidation inhibitor potentially for the treatment of hepatic fibrosis. |
| M5408 | Aminoguanidine hydrochloride | Aminoguanidine hydrochloride is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone. |
| M5183 | Kuwanon A | Kuwanon A |
| M5154 | Diphenyleneiodonium chloride | Diphenyleneiodonium chloride (DPI) is an irreversible inhibitor of iNOS and eNOS with IC50 values of 50 nM and 0.3 µM, respectively. |
| M4755 | Apioside | Apiin is one of the main components of Apium graveolens leaves and has anti-inflammatory properties. Apiin could inhibit nitrite (NO) production in vitro (IC50 = 0.08 mg/mL) and iNOS expression in LPS-activated J774.A1 cells (IC50 = 0.049 mg/mL). |
| M4712 | Irisflorentin | Irisflorentin, a naturally occurring isoflavone, is an abundant active ingredient in Rhizoma Belamcandae. Irisflorentin significantly reduced the transcription and translation levels of iNOS and NO production. |
| M4510 | Madecassic-acid | Madecassic acid was isolated from Centella asiatica (umbelliferae). Madecassic acid showed inhibition of iNOS, COX-2, TNF-α, IL-1beta and IL-6, and had anti-inflammatory effect by down-regulation of NF-κB activation in RAW 264.7 macrophages. |
| M4500 | Crocin-II | Crocin II, isolated from the fruit of Gardenia jasminoides, has antioxidant, anticancer and antidepressant activities. Crocin II inhibited NO production with IC50 value of 31.1 μM. Crocin II inhibited the expression of iNOS and COX-2 protein and M-RNA. |
| M4390 | Imperatorin | Imperatorin is a potent NO synthesis inhibitor with an IC50 of 9.2 μmol and a BChE inhibitor with an IC50 of 31.4 μmol. Imperatorin is a weak agonist of TRPV1 with an EC50 of 12.6±3.2 μM. |
| M2357 | 2-Thiouracil | 2-Thiouracil is a thiolated uracil derivative that is a known antihyperthyroid agent. |
| M38996 | Kazinol B | Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research. |
| M38995 | Physalin O | Physalin O is a physalin that can be isolated from Physalis angulata. Physalin O shows cytotoxicity to Hep G2 and MCF-7 cancer cells with IC50 values of 31.1 and 11.4 µM, respectively. Physalin O inhibits the production of nitric oxide (NO) and shows anti-inflammatory activities. |
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