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GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM).
| Molecular Weight | 219.3 |
| Formula | C8H17N3O2S |
| CAS Number | 210354-22-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL Water ≥ 62 mg/mL |
| Storage | 4°C, sealed |
| Related NO Synthase Products |
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| FeTPPS
FeTPPS acts as a peroxynitrite scavenger and anti-nitrating agent in vivo. FeTPPS reduces nitric oxide (NO) production and apoptosis process. FeTPPS possesses evident neuroprotective effects in a experimental model of spinal cord damage. |
| (S)-ZLc002
(S)-ZLc002 is a S-enantiomer of ZLc-002. |
| NOS-IN-1
NOS-IN-1 is a potent and orally active NO synthase (NOS) isoforms inhibitor with IC50s of 0.1 μM, 1.1 μM, and 0.2 μM for human iNOS (hiNOS), heNOS and hnNOS, respectively. |
| ARL 17477
ARL-17477 is a dual inhibitor of NOS1and the autophagy-lysosomal system with anticancer activity and can inhibit tumor growth in KRAS-mutated cancers. |
| NOS1-IN-1
NOS1-IN-1 is a selective and cell-permeable nNOS inhibitor with a Ki of 120 nM. |
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