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Amcinonide

Cat. No. M20791
Amcinonide Structure
Synonym:

Cyclocort, CL-34699

Size Price Availability Quantity
50mg USD 85  USD85 In stock
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Quality Control & Documentation
Biological Activity

Amcinonide (Cyclocort, CL-34699) is an inhibitor of nitric oxide (NO) release from activated microglia with IC50 of 3.38 nM.

Chemical Information
Molecular Weight 502.57
Formula C28H35FO7
CAS Number 51022-69-6
Solubility (25°C) DMSO 84 mg/mL
Water 84 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] No authors listed. Amcinonide

[2] A C Huntley, et al. Cutis. Amcinonide vs. betamethasone dipropionate ointments in the treatment of psoriasis

[3] R Hayakawa, et al. Contact Dermatitis. Allergic contact dermatitis from amcinonide

[4] Y Kubo, et al. Contact Dermatitis. Contact allergy to amcinonide

[5] D Lubach, et al. Dermatologica. Investigations on the development and regression of corticosteroid-induced thinning of the skin in various parts of the human body during and after topical application of amcinonide

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Keywords: Amcinonide, Cyclocort, CL-34699 supplier, NOS, inhibitors, activators


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