Amcinonide (Cyclocort, CL-34699) is an inhibitor of nitric oxide (NO) release from activated microglia with IC50 of 3.38 nM.
|Solubility (25°C)||DMSO 84 mg/mL
Water 84 mg/mL
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 No authors listed. Amcinonide
 A C Huntley, et al. Cutis. Amcinonide vs. betamethasone dipropionate ointments in the treatment of psoriasis
 R Hayakawa, et al. Contact Dermatitis. Allergic contact dermatitis from amcinonide
 Y Kubo, et al. Contact Dermatitis. Contact allergy to amcinonide
 D Lubach, et al. Dermatologica. Investigations on the development and regression of corticosteroid-induced thinning of the skin in various parts of the human body during and after topical application of amcinonide
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