Free shipping on all orders over $ 500

Amcinonide

Cat. No. M20791
Amcinonide Structure
Synonym:

Cyclocort, CL-34699

Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Amcinonide (Cyclocort, CL-34699) is an inhibitor of nitric oxide (NO) release from activated microglia with IC50 of 3.38 nM.

Chemical Information
Molecular Weight 502.57
Formula C28H35FO7
CAS Number 51022-69-6
Solubility (25°C) DMSO 84 mg/mL
Water 84 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] No authors listed. Amcinonide

[2] A C Huntley, et al. Cutis. Amcinonide vs. betamethasone dipropionate ointments in the treatment of psoriasis

[3] R Hayakawa, et al. Contact Dermatitis. Allergic contact dermatitis from amcinonide

[4] Y Kubo, et al. Contact Dermatitis. Contact allergy to amcinonide

[5] D Lubach, et al. Dermatologica. Investigations on the development and regression of corticosteroid-induced thinning of the skin in various parts of the human body during and after topical application of amcinonide

Related NOS Products
MAHMA NONOate

MAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP.

Inflexuside B

Inflexuside B, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages

Bendazol

Bendazol (2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan) is a hypotensive drug that enhances NO synthase activity in renal glomeruli and collecting tubules. Bendazol inhibits the progression of form-deprivation myopia (FDM) and suppresses the upregulation of HIF-1α.

Syzalterin

Syzalterin is an inhibitor of NO production with an IC50 of 1.87 μg/mL.

L-NIO dihydrochloride

L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively.

  Catalog
Abmole Inhibitor Catalog




Keywords: Amcinonide, Cyclocort, CL-34699 supplier, NOS, inhibitors, activators

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.