Free shipping on all orders over $ 500


Cat. No. M20791
Amcinonide Structure

Cyclocort, CL-34699

Size Price Availability Quantity
50mg USD 85  USD85 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Amcinonide (Cyclocort, CL-34699) is an inhibitor of nitric oxide (NO) release from activated microglia with IC50 of 3.38 nM.

Chemical Information
Molecular Weight 502.57
Formula C28H35FO7
CAS Number 51022-69-6
Solubility (25°C) DMSO 84 mg/mL
Water 84 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] No authors listed. Amcinonide

[2] A C Huntley, et al. Cutis. Amcinonide vs. betamethasone dipropionate ointments in the treatment of psoriasis

[3] R Hayakawa, et al. Contact Dermatitis. Allergic contact dermatitis from amcinonide

[4] Y Kubo, et al. Contact Dermatitis. Contact allergy to amcinonide

[5] D Lubach, et al. Dermatologica. Investigations on the development and regression of corticosteroid-induced thinning of the skin in various parts of the human body during and after topical application of amcinonide

Related NO Synthase Products

6-Methoxynaringenin is an aerial part of Scutellaria barbata D. Don (Lamiaceae) and inhibits NO production efficiently with an IC50 value of 25.8 μM.


Camstatin, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal nitric oxide (NO) synthase.


N'-Nitro-D-arginine, a nitric oxide synthesis inhibitor, also is a vasodilator that relaxes the smooth muscles and increases blood flow to the penis, improving erections.


DETA NONOate is an exogenous nitric oxide (NO) donor that activates inward currents in cultured rat cerebellar granule cells and increases cGMP production in vascular smooth muscle cells.


N-cis-Feruloyl tyramine (cis-N-(4-Hydroxyphenethyl) ferulamide) is a natural phenolic compound, exhibits modest inhibitory activity on LPS-activated NO production in RAW 264.7 cells.

Abmole Inhibitor Catalog

Keywords: Amcinonide, Cyclocort, CL-34699 supplier, NO Synthase, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.