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SNAP

Cat. No. M9588
SNAP Structure
Synonym:

S-Nitroso-N-acetyl-penicillamine

Size Price Availability Quantity
25mg USD 70  USD70 In stock
50mg USD 120  USD120 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

SNAP is a nitrosothiol derivative, releases nitric oxide, acts as a stable inhibitor of platelet aggregation.

Chemical Information
Molecular Weight 220.25
Formula C7H12N2O4S
CAS Number 67776-06-1
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage -20°C, dry, sealed, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rebecca L Rivera, et al. Effect of Supplemental Nutrition Assistance Program-Education (SNAP-Ed) on food security and dietary outcomes

[2] Katherine Najera, et al. SNAP-25 in Major Psychiatric Disorders: A Review

[3] Anna Kdkov, et al. The SNAP-25 Protein Family

[4] Thomas P O'Connor. SNAP Assay Technology

[5] A Hodel. SNAP-25

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  Catalog
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Keywords: SNAP, S-Nitroso-N-acetyl-penicillamine supplier, NOS, inhibitors, activators


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