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SNAP is a nitrosothiol derivative, releases nitric oxide, acts as a stable inhibitor of platelet aggregation.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 220.25 |
| Formula | C7H12N2O4S |
| CAS Number | 67776-06-1 |
| Purity | >98% |
| Solubility | DMSO ≥ 90 mg/mL |
| Storage | -20°C, dry, sealed, protect from light |
[2] Katherine Najera, et al. SNAP-25 in Major Psychiatric Disorders: A Review
[3] Anna Kdkov, et al. The SNAP-25 Protein Family
| Related NOS Products |
|---|
| Amcinonide
Amcinonide (Cyclocort, CL-34699) is an inhibitor of nitric oxide (NO) release from activated microglia with IC50 of 3.38 nM. |
| Bendazol
Bendazol (2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan) is a hypotensive drug that enhances NO synthase activity in renal glomeruli and collecting tubules. Bendazol inhibits the progression of form-deprivation myopia (FDM) and suppresses the upregulation of HIF-1α. |
| Syzalterin
Syzalterin is an inhibitor of NO production with an IC50 of 1.87 μg/mL. |
| L-NIO dihydrochloride
L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively. |
| L-NIL
L-NIL is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS. |
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