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Cat. No. M22492
MAHMA NONOate Structure
Size Price Availability
10mg USD 155  USD155 1-2 Weeks
25mg USD 240  USD240 1-2 Weeks
50mg USD 380  USD380 1-2 Weeks
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Quality Control & Documentation
Biological Activity

MAHMA NONOate is a NO donor. MAHMA NONOate (0.1 nM-100 μM) dose-dependently inhibits platelet aggregation induced by either collagen or ADP. MAHMA NONOate shows inhibitory effects to pulmonary artery and platelet aggregation with log IC50 values of 7.18 and 6.16, respectively.

Chemical Information
Molecular Weight 204.27
Formula C8H20N4O2
CAS Number 146724-86-9
Solubility (25°C)
Storage -70°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Anna Kobsar, et al. Eur J Pharmacol. Specific inhibitory effects of the NO donor MAHMA/NONOate on human platelets

[2] Kerry L Homer, et al. Eur J Pharmacol. Platelet inhibitory effects of the nitric oxide donor drug MAHMA NONOate in vivo in rats

[3] Kerry L Homer, et al. Br J Pharmacol. Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate

[4] K L Homer, et al. Br J Pharmacol. Cyclic GMP-independent relaxation of rat pulmonary artery by spermine NONOate, a diazeniumdiolate nitric oxide donor

[5] K Homer, et al. Eur J Pharmacol. In vitro comparison of two NONOates (novel nitric oxide donors) on rat pulmonary arteries

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Abmole Inhibitor Catalog

Keywords: MAHMA NONOate supplier, NOS, inhibitors, activators

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