Free shipping on all orders over $ 500

Luteolin 5-O-glucoside

Cat. No. M10999
Luteolin 5-O-glucoside Structure
Size Price Availability Quantity
5mg USD 600  USD600 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

Luteolin 5-O-glucoside from Cirsium maackii has anti-inflammatory activity. Luteolin 5-O-glucoside inhibits LPS-induced NO production and t-BHP-induced ROS production. Luteolin 5-O-glucoside acts on macrophages and also inhibits iNOS and COX-2 expression.

Chemical Information
Molecular Weight 448.38
Formula C21H20O11
CAS Number 20344-46-1
Form Solid
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Nur Aziz, et al. J Ethnopharmacol. Anti-inflammatory effects of luteolin: A review of in vitro, in vivo, and in silico studies

[2] Handan Gokben Sevindik, et al. Chem Pharm Bull (Tokyo). Phtytochemical Studies and Quantitative HPLC Analysis of Rosmarinic Acid and Luteolin 5-O-β-D-Glucopyranoside on Thymus praecox subsp. grossheimii var. grossheimii

[3] Megumi Ono, et al. Nat Prod Commun. Quantitative flavonoid variation accompanied by change of flower colors in Edgeworthia chrysantha, Pittosporum tobira and Wisteria floribunda

[4] Xiao-Jing Zhou, et al. Food Chem. Structural characterisation and antioxidant activity evaluation of phenolic compounds from cold-pressed Perilla frutescens var. arguta seed flour

[5] Hyun Ah Jung, et al. Food Chem Toxicol. Anti-inflammatory activity of Korean thistle Cirsium maackii and its major flavonoid, luteolin 5-O-glucoside

Related NO Synthase Products
6-Methoxynaringenin

6-Methoxynaringenin is an aerial part of Scutellaria barbata D. Don (Lamiaceae) and inhibits NO production efficiently with an IC50 value of 25.8 μM.
Camstatin

Camstatin, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal nitric oxide (NO) synthase.
N'-Nitro-D-arginine

N'-Nitro-D-arginine, a nitric oxide synthesis inhibitor, also is a vasodilator that relaxes the smooth muscles and increases blood flow to the penis, improving erections.
DETA NONOate

DETA NONOate is an exogenous nitric oxide (NO) donor that activates inward currents in cultured rat cerebellar granule cells and increases cGMP production in vascular smooth muscle cells.
Cis-N-Feruloyltyramine

N-cis-Feruloyl tyramine (cis-N-(4-Hydroxyphenethyl) ferulamide) is a natural phenolic compound, exhibits modest inhibitory activity on LPS-activated NO production in RAW 264.7 cells.
  Catalog
Abmole Inhibitor Catalog




Keywords: Luteolin 5-O-glucoside supplier, NO Synthase, inhibitors, activators

 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.