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1400W dihydrochloride

Cat. No. M10446
1400W dihydrochloride Structure

N-(3-(AMinoMethyl)benzyl)acetaMidine Dihydrochloride

Size Price Availability Quantity
5mg USD 60  USD60 In stock
10mg USD 100  USD100 In stock
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Biological Activity

1400W dihydrochloride is a potent and selective inhibitor of human inducible NO synthase with Ki values of 7 nM.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 250.17
Formula C10H15N3.2HCl
CAS Number 214358-33-5
Purity 99.60%
Solubility Water 50 mg/mL
DMSO 20 mg/mL
Storage at -20°C

[1] Qinghai Shi, et al. Behav Brain Res. 1400W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia

[2] Alma Rus, et al. Redox Rep. Inducible NOS inhibitor 1400W reduces hypoxia/re-oxygenation injury in rat lung

[3] E P Garvey, et al. J Biol Chem. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo

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Syzalterin is an inhibitor of NO production with an IC50 of 1.87 μg/mL.

L-NIO dihydrochloride

L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively.


L-NIL is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS.

Abmole Inhibitor Catalog

Keywords: 1400W dihydrochloride, N-(3-(AMinoMethyl)benzyl)acetaMidine Dihydrochloride supplier, NOS, inhibitors

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