Certificate of Analysis
| Product Name: | 1400W dihydrochloride |
| Catalog Number: | M10446 |
| CAS Number: | 214358-33-5 |
Physical and Chemical Properties
| Formula: | C10H15N3.2HCl |
| Molecular Weight: | 250.17 |
| Solubility: | Water 50 mg/mL; DMSO 20 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.60% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | 1400W dihydrochloride is a potent and selective inhibitor of human inducible NO synthase with Ki values of 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |