2, 4-diamino-6-hydroxypyrimidine is a specific inhibitor of GTP cyclohydrolase I, a rate-limiting enzyme involved in de novo protein synthesis. 2, 4-diamino-6-hydroxypyrimidine can block the synthesis of Tetrahydrobiopterin (BH4) and inhibit the production of NO.
| Molecular Weight | 126.12 |
| Formula | C4H6N4O |
| CAS Number | 56-06-4 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 20 mg/mL |
| Storage | 4°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related NO Synthase Products |
|---|
| 6-Methoxynaringenin
6-Methoxynaringenin is an aerial part of Scutellaria barbata D. Don (Lamiaceae) and inhibits NO production efficiently with an IC50 value of 25.8 μM. |
| Camstatin
Camstatin, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal nitric oxide (NO) synthase. |
| N'-Nitro-D-arginine
N'-Nitro-D-arginine, a nitric oxide synthesis inhibitor, also is a vasodilator that relaxes the smooth muscles and increases blood flow to the penis, improving erections. |
| DETA NONOate
DETA NONOate is an exogenous nitric oxide (NO) donor that activates inward currents in cultured rat cerebellar granule cells and increases cGMP production in vascular smooth muscle cells. |
| Cis-N-Feruloyltyramine
N-cis-Feruloyl tyramine (cis-N-(4-Hydroxyphenethyl) ferulamide) is a natural phenolic compound, exhibits modest inhibitory activity on LPS-activated NO production in RAW 264.7 cells. |
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