NO Synthase Nitric oxide synthase (NOS)

Cat.No.	Name	Information
M10446	1400W dihydrochloride	1400W dihydrochloride is a potent and selective inhibitor of human inducible NO synthase with Ki values of 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex.
M6561	Carboxy-PTIO, potassium salt	Carboxy-PTIO, potassium salt is a stable, water-soluble deactivator of NO.
M5408	Aminoguanidine hydrochloride	Aminoguanidine hydrochloride is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone.
M5183	Kuwanon A	Kuwanon A
M5154	Diphenyleneiodonium chloride	Diphenyleneiodonium chloride (DPI) is an irreversible inhibitor of iNOS and eNOS with IC50 values of 50 nM and 0.3 µM, respectively.
M4755	Apioside	Apiin is one of the main components of Apium graveolens leaves and has anti-inflammatory properties. Apiin could inhibit nitrite (NO) production in vitro (IC50 = 0.08 mg/mL) and iNOS expression in LPS-activated J774.A1 cells (IC50 = 0.049 mg/mL).
M4712	Irisflorentin	Irisflorentin, a naturally occurring isoflavone, is an abundant active ingredient in Rhizoma Belamcandae. Irisflorentin significantly reduced the transcription and translation levels of iNOS and NO production.
M4510	Madecassic-acid	Madecassic acid was isolated from Centella asiatica (umbelliferae). Madecassic acid showed inhibition of iNOS, COX-2, TNF-α, IL-1beta and IL-6, and had anti-inflammatory effect by down-regulation of NF-κB activation in RAW 264.7 macrophages.
M4500	Crocin-II	Crocin II, isolated from the fruit of Gardenia jasminoides, has antioxidant, anticancer and antidepressant activities. Crocin II inhibited NO production with IC50 value of 31.1 μM. Crocin II inhibited the expression of iNOS and COX-2 protein and M-RNA.
M4390	Imperatorin	Imperatorin is a potent NO synthesis inhibitor with an IC50 of 9.2 μmol and a BChE inhibitor with an IC50 of 31.4 μmol. Imperatorin is a weak agonist of TRPV1 with an EC50 of 12.6±3.2 μM.
M2357	2-Thiouracil	2-Thiouracil is a thiolated uracil derivative that is a known antihyperthyroid agent.
M56381	(S)-ZLc002	(S)-ZLc002 is a S-enantiomer of ZLc-002.
M56379	NOS-IN-1	NOS-IN-1 is a potent and orally active NO synthase (NOS) isoforms inhibitor with IC50s of 0.1 μM, 1.1 μM, and 0.2 μM for human iNOS (hiNOS), heNOS and hnNOS, respectively.
M56378	ARL 17477	ARL-17477 is a dual inhibitor of NOS1and the autophagy-lysosomal system with anticancer activity and can inhibit tumor growth in KRAS-mutated cancers.
M56377	NOS1-IN-1	NOS1-IN-1 is a selective and cell-permeable nNOS inhibitor with a Ki of 120 nM.
M56376	Aminoguanidine	Aminoguanidine (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase.
M56375	MEG hemisulfate	MEG (Mercaptoethylguanidine) hemisulfate is a potent and selective inhibitor of the inducible NO synthase (iNOS), with EC50s of 11.5, 110, and 60 μM for iNOS, ecNOS, and bNOS respectively in tissue homogenates.
M56374	Nω-Propyl-L-arginine	Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM.
M56373	7-Nitroindazole sodium	7-Nitroindazole sodium is a selective nNOS inhibitor with antinociceptive and cardiovascular effects.
M56372	GW274150 dihydrochloride	GW274150 (dihydrochloride) is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM).
M56371	AR-C102222 hydrochloride	AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM.

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NO Synthase Nitric oxide synthase (NOS)

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