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Diphenyleneiodonium chloride

Cat. No. M5154
Diphenyleneiodonium chloride Structure
Synonym:

DPI

Size Price Availability Quantity
10mg USD 77  USD77 In stock
50mg USD 265  USD265 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Diphenyleneiodonium chloride (DPI) is an irreversible inhibitor of iNOS and eNOS with IC50 values of 50 nM and 0.3 µM, respectively. DPI chloride has been used to inhibit other flavoenzymes such as neutrophil NADPH oxidase and to bind strongly to flavoproteins. DPI chloride is thus a powerful and specific inhibitor of several important enzymes, including NADPH cytochrome P450 oxidoreductase, NADPH oxidases and NADPH-ubiquinone oxidoreductase.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 314.55
Formula C12H8I.Cl
CAS Number 4673-26-1
Purity >98%
Solubility DMSO 6 mg/mL (with warming)
Storage at -20°C
References

[1] Ye C, et al. J Pharmacol Exp Ther. Identification of a novel small-molecule agonist for human G protein-coupled receptor 3.

[2] Tew DG. Biochemistry. Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications.

[3] Wang YX, et al. Br J Pharmacol. Inhibitory actions of diphenyleneiodonium on endothelium-dependent vasodilatations in vitro and in vivo.

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Keywords: Diphenyleneiodonium chloride, DPI supplier, TRP Channel, inhibitors

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