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Carboxy-PTIO, potassium salt is a a stable, water-soluble free radical that reacts stoichiometrically with NO. Almost twice as strong an inhibitor as N(ω)-nitroarginine or N-methylarginine. Carboxy-PTIO potassium can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model.
| Molecular Weight | 315.39 |
| Formula | C14H16KN2O4 |
| CAS Number | 148819-94-7 |
| Form | Solid |
| Solubility (25°C) | Water 25 mg/mL DMSO 10 mg/mL |
| Storage | -20°C, dry, sealed |
| Related NO Synthase Products |
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| FeTPPS
FeTPPS acts as a peroxynitrite scavenger and anti-nitrating agent in vivo. FeTPPS reduces nitric oxide (NO) production and apoptosis process. FeTPPS possesses evident neuroprotective effects in a experimental model of spinal cord damage. |
| (S)-ZLc002
(S)-ZLc002 is a S-enantiomer of ZLc-002. |
| GW274150
GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). |
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NOS-IN-1 is a potent and orally active NO synthase (NOS) isoforms inhibitor with IC50s of 0.1 μM, 1.1 μM, and 0.2 μM for human iNOS (hiNOS), heNOS and hnNOS, respectively. |
| ARL 17477
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