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HTHQ and vitamin E attenuated interleukin-1beta-induced iNOS protein expression in cultured hepatocytes, the potency of HTHQ being 10-times higher than that of vitamin E. HTHQ may prevent tumor production induced by AP and NaNO2 more effectively than ascorbic acid.
In vivo, treatment with HTHQ potently inhibits PhIP-induced mammary carcinogenesis in female rats without prior initiation treatment. HTHQ administration shows reduced mRNA level of PDGF, α-SMA and TGF-β than DMN-induced hepetic fibrosis animals in the liver tissue.
| Molecular Weight | 236.35 |
| Formula | C15H24O2 |
| CAS Number | 148081-72-5 |
| Solubility (25°C) | DMSO: ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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