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Tomeglovir is a novel nonnucleosidic inhibitor of human cytomegalovirus replication. Tomeglovir is a potent anti-CMV agent, inhibiting processing of viral DNA-concatemers, with IC50s of 0.34 μM and 0.039 μM for HCMV and MCMV.
Tomeglovir (3, 10, 30, 100 mg/kg; p.o.) dose-dependently reduces MCMV-DNA in salivary glands, livers and kidneys of MCMV-infected NOD-SCID mice, and prolongs the survival of the mice. Tomeglovir (10, 25 and 50 mg/kg) shows antiviral activity in the hollow fiber mouse model.
| Molecular Weight | 441.54 |
| Formula | C23H27N3O4S |
| CAS Number | 233254-24-5 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Vincent C Emery, et al. Focus on new drugs in development against human cytomegalovirus
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