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Entecavir Monohydrate

Cat. No. M1707
Entecavir Monohydrate Structure


Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 54  USD54 In stock
10mg USD 80  USD80 In stock
50mg USD 190  USD190 In stock
100mg USD 306  USD306 In stock
200mg USD 450  USD450 In stock
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Quality Control & Documentation
Biological Activity

Entecavir Hydrate is a class of antiviral compounds.

Product Citations
Chemical Information
Molecular Weight 295.29
Formula C12H15N5O3.H2O
CAS Number 209216-23-9
Solubility (25°C) DMSO 45 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Tsai et al. Clinicoecon Outcomes Res. Cost-effectiveness of entecavir versus adefovir for the treatment of chronic hepatitis B in patients with decompensated cirrhosis from a third-party US payer perspective.

[2] Shin et al. J Viral Hepat. Prediction of response to entecavir therapy in patients with HBeAg-positive chronic hepatitis B based on on-treatment HBsAg, HBeAg and HBV DNA levels.

[3] Ko et al. Scand J Gastroenterol. Long-term impact of entecavir monotherapy in chronic hepatitis B patients with a partial virologic response to entecavir therapy.

[4] Jayakumar et al. J Lab Physicians. Laboratory evaluation of three regimens of treatment of chronic hepatitis B: tenofovir, entecavir and combination of Lamivudine and adefovir.

[5] Chung et al. Clin Mol Hepatol. Clinical impacts of hazardous alcohol use and obesity on the outcome of entecavir therapy in treatment-naïve patients with chronic hepatitis B infection.

[6] Karatayli et al. Antivir Ther. Clonal analysis of the quasispecies of antiviral resistant HBV genomes in patients with entecavir resistance during rescue treatment and successful treatment of entecavir resistance with tenofovir.

[7] Marengo et al. Antivir Ther. Clinical and virologic response to entecavir in HBV related chronic hepatitis or cirrhosis: data from the clinical practice in a single centre cohort.

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