All AbMole products are for research use only, cannot be used for human consumption.
Mozavaptan (OPC-31260) is a novel, orally effective, nonpeptide vasopressin V2 receptor antagonist. The V2 receptor subtype is important in water retention, cardiac remodeling in congestive heart failure (CHF), and renal hemodynamic alterations, and is considered a target for polysystic kidney disease. Mozavaptan (OPC-31260) inhibited the antidiuretic action of exogenously administered AVP in water-loaded, alcohol-anaesthetized rats in a dose-dependent manner. Mozavaptan (OPC-31260) caused a competitive displacement of [3H]-AVP binding to both V1 and V2 receptors with IC50 values of 1.2 ± 0.2 × 10-6 M and 1.4 ± 0.2 × 10-8 M, respectively.
| Molecular Weight | 427.53 |
| Formula | C27H29N3O2 |
| CAS Number | 137975-06-5 |
| Solubility (25°C) | DMSO 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Carles Villabona. Vasopressin receptor antagonists: the vaptans
| Related Vasopressin Receptor Products |
|---|
| Conivaptan
Conivaptan (YM 087 free base) is antagonist for vasopressin V1A receptor and vasopressin V2 receptor. |
| d[Cha4]-AVP
d[Cha4]-AVP is a potent and selective vasopressin (AVP) V1b receptor agonist with a Ki of 1.2 nM for human V1b receptor. |
| Big Endothelin-1 (1-38), human
Big Endothelin-1 (1-38), human is the precursor of endothelin-1. |
| (d(CH2)51, Tyr(Me)2, Arg8)-Vasopressin
(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin (SKF 100273) is a vasopressin V1 receptor selective antagonist. |
| [Asu1, 6-Arg8]Vasopressin
[Asu1,6-Arg8]Vasopressin is an vasopressin agonist which potentiates cyclic AMP accumulation and ACTH release induced by corticotropin-releasing factor (CRF) in rat anterior pituitary cells in culture. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
