About 32 results found for searched term "PIT 1" (0.086 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1667 | Sapitinib (AZD8931) | EGFR/HER2 |
| AZD-8931 | ||
| AZD8931 (Sapitinib) is an equipotent, reversible inhibitor of Signaling by EGFR, ERBB2 (HER2), and ERBB3 with IC50 of 4, 3, 4 nM respectively. | ||
| M3380 | Pitavastatin Calcium | Autophagy |
| Pitavastatin hemicalcium; NK-104 | ||
| Pitavastatin Calcium is a new type of statin. | ||
| M7142 | PIT 1 | Others |
| PIT 1 is a pIP 3 antagonist. Blocks PIP 3-PH interaction; inhibits Akt signaling. | ||
| M1832 | Maropitant | Neurokinin Receptor |
| Maropitant (Cerenia) is a novel, selective neurokinin type-1 (NK1) receptor antagonist. | ||
| M1922 | MGCD265 | c-Met |
| MGCD265 is a novel multitargeted receptor tyrosine kinase (RTK) inhibitor that targets the mesenchymal epithelial transition (c-Met) and the vascular endothelial growth factor (VEGF) receptors (VEGFR1, VEGFR2, and VEGFR3). | ||
| M2712 | Fosaprepitant dimeglumine salt | Neurokinin Receptor |
| MK-0517 dimeglumine salt; L-758,298 dimeglumine salt | ||
| Fosaprepitant is a water-soluble phosphoryl procompound for Aprepitant which is a NK1 antagonist.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M3882 | Netupitant | Neurokinin Receptor |
| CHEBI441603, CID6451149, D05152 | ||
| Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity with Ki of 0.95 nM. | ||
| M1569 | Monohydroxy Netupitant | Neurokinin Receptor |
| Monohydroxy Netupitant is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist. | ||
| M6457 | AR-C 118925XX | P2 Receptor |
| ARC118925XX | ||
| AR-C 118925XX is a selective, competitive P2Y2 receptor antagonist. AR-C 118925XX is inactive against a panel of 37 other receptors at a concentration of 10 μM. AR-C 118925XX inhibits ATP-γS-induced mucin secretion in bronchial epithelial cells (IC50 = 1 μM). AR-C 118925XX inhibits P2Y2 receptor-induced β-arrestin translocation in vitro (pA2 = 37.2-51.3 nM). | ||
| M8439 | SMI481 | Others |
| SMI481 is a selective small-molecule inhibitor (SMI) of the yeast phosphatidylinositol transfer protein (PITP) Sec14, a key regulator of phosphoinositide signaling, regulating membrane trafficking through the trans-Golgi network and endosomal systems. | ||
| M9019 | Rolapitant | Neurokinin Receptor |
| SCH 619734 | ||
| Rolapitant (SCH619734) is an orally bioavailable, centrally-acting, selective neurokinin 1 receptor (NK1-receptor) antagonist with a Ki of 0.66 nM. | ||
| M9185 | Serlopitant | Neurokinin Receptor |
| VPD-737; MK-0594 | ||
| Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist. | ||
| M10112 | Cinromide | Others |
| trans-3-Bromo-N-ethylcinnamamide | ||
| Cinromide is an inhibitor of epithelial neutral amino acid transporter B0AT1 (SLC6A19) with IC50 of 0.5 μM. | ||
| M10714 | Pitolisant | Histamine Receptor |
| Tiprolisant | ||
| Pitolisant is a potent and selective non-imidazole recombinant hentistamine H3 receptor reversed agonist,Ki 0.16 nM. | ||
| M10863 | NCGC00378430 | Others |
| NCGC00378430 is a potent inhibitor of the SIX1/EYA2 interaction. NCGC00378430 partially reverses SIX1 overexpression-mediated transcription and metabolic profiling, and reverses SIX1-induced TGF-β signaling and epithelial-interstitial transformation (EMT). NCGC00378430 inhibits SIX1-mediated breast cancer metastasis in mouse models. | ||
| M11191 | Recombinant Mouse IL-1β (E. coli) | Cytokines and Growth Factors |
| IL1B; IL-1; IL1-BETA | ||
| Interleukin-1 Beta (IL-1β) is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. ED50 < 10.0 pg/ml, measured by the dose-dependent stimulation of mouse D10.G4.1 helper T cells, corresponding to a specific activity of 1.0 × 108 IU/mg. | ||
| M11488 | Recombinant Human PDGF-BB (E. coli) | Cytokines and Growth Factors |
| PDGFBB; PDGF-BB | ||
| PDGF has three subforms: PDGF-AA, PDGF-BB, PDGF-AB. It is involved in a number of biological processes, including hyperplasia, embryonic neuron development, chemotaxis, and respiratory tubule epithelial cell development. Protein structure: PDGF-BB (Ser82-Thr190) | ||
| M11491 | Recombinant Mouse IL-33 (E. coli, 98%) | Cytokines and Growth Factors |
| IL33; C9orf26; DVS27; IL1F11 | ||
| Interleukin-33 (IL-33) is a proinflammatory cytokine that belongs to the IL-1 family. IL-33 is expressed in a variety of cells, including epithelial and endothelial cells, smooth muscle cells, macrophages and fibroblasts. The ED50 measured by D10S cell proliferation assay was less than 0.5 ng/ mL, corresponding to a specific activity of > 2.0 × 106IU/mg. | ||
| M13996 | Pitolisant hydrochloride | Histamine Receptor |
| Ciproxidine; BF 2649 | ||
| Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM). | ||
| M15093 | Recombinant Human EpCAM/Trop1 (Expi293, C-His) | Cytokines and Growth Factors |
| CD326 antigen; CD326; EGP; EGP-2 | ||
| Epithelial Cellular Adhesion Molecule (EpCAM), also known as KS1/4, gp40, GA733-2, 17-1A, and TROP‑1, is a 40 kDa transmembrane glycoprotein that consists of a 242 amino acid (aa) extracellular domain with two EGF‑like repeats, a 23 aa transmembrane segment, and a 26 aa cytoplasmic domain. | ||
| M16449 | Harringtonolide | FAK |
| Harringtonolide is a potent RACK1 inhibitor (IC50=39.66 μM in A375 cells). Harringtonolide inhibits the epithelial-mesenchymal transition (EMT) process and cell proliferation by affecting the interaction between FAK and RACK1. | ||
| M19986 | Recombinant Human CXCL6 (HEK293, C-6His) | Cytokines and Growth Factors |
| C-X-C Motif Chemokine 6; Chemokine Alpha 3 | ||
| Chemokine (C-X-C-Motif) Ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family. CXCL6 can promote the release of MMP-9 from granulocytes indicating its potential role as an inflammatory mediator. It functionally uses both of the IL-8/CXCL8 receptors to chemoattract neutrophils but that is structurally most related to epithelial cell-derived neutrophil attractant-78 (ENA-78)/CXCL5. Accession: P80162. | ||
| M20765 | Lavendustin B | Integrase |
| Lavendustin B inhibits HIV-1 integrase (IN) interaction with its cognate cellular cofactor lens epithelium-derived growth factor (LEDGF/p75). Lavendustin B is an inhibitor of Tyrosine Kinase and also a competitive inhibitor of glucose transporter 1 (Glut1). | ||
| M21094 | Recombinant Rat IL-1β (E. coli) | Cytokines and Growth Factors |
| Interleukin-1 Beta; IL1F2 | ||
| Interleukin-1β (IL-1β) is a non-secreted pro-inflammatory cytokine produced primarily by activated macrophages as well as neutrophils, epithelial cells and endothelial cells. Measured by a cell proliferation assay using mouse D10S cells, the ED50 is < 10.0 pg/ml, corresponding to a specific activity of > 1.0 × 108 units/mg. | ||
| M21215 | CP-628006 | CFTR |
| CP-628006 is a CFTR small molecule enhancer that enhances CFTR function in human bronchial epithelial (hBE) cells and restores ATP-dependent gated channels in cystic fibrosis mutant G551D-CFTR. It can be used in cystic fibrosis (CF) related studies. | ||
| M21262 | FT3967385 | Deubiquitinase |
| FT385 | ||
| FT3967385 is a novel USP30 inhibitor that recapitulates the genetic deletion of USP30 and triggers mitochondrial ubiquitination of PINK1-PARKIN amplification. | ||
| M22349 | Fosaprepitant | Neurokinin Receptor |
| L-758298; MK-0517 | ||
| Fosaprepitant is a precursor compound to Aprepitant and a neurokinin-1 receptor (NK1) antagonist that can be used in studies related to nausea and vomiting. | ||
| M22459 | Recombinant Human EGF Protein (HEK293, hFc) | Cytokines and Growth Factors |
| EGF is the founding member of the EGF-family of proteins. EGF is a growth factor that stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. It results in cellular proliferation, differentiation, and survival. Measured in a cell proliferation assay using Balb/C 3T3 mouse embryonic fibroblast cells, the ED50 for this effect is typically 0.3-1.5 ng/mL. | ||
| M22510 | Recombinant Mouse IL-1α Protein (E. coli) | Cytokines and Growth Factors |
| Interleukin-1 alpha | ||
| Interleukin-1 alpha (IL-1α) is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 2.0 pg/ml, corresponding to a specific activity of > 5.0 × 108 IU/mg. | ||
| M24596 | Gatipotuzumab | Others |
| PankoMab | ||
| Gatipotuzumab (PankoMab) is a humanized monoclonal antibody which recognizes the tumor-specific epitope of mucin-1 (TA-MUC1). Gatipotuzumab reveals a potent tumor-specific antibody-dependent cell cytotoxicity (ADCC). | ||
| M25066 | Apitegromab | Others |
| SRK-015 | ||
| Apitegromab (SRK-015) is an anti-promyostatin monoclonal antibody. Apitegromab can be used for the research of neuromuscular disease including spinal muscular atrophy. | ||
| M55622 | Recombinant Human BMPRIA/ALK-3/CD292 Protein (HEK293, C-His) | Cytokines and Growth Factors |
| Bone Morphogenetic Protein Receptor type IA; Activin receptor-Like Kinase 3; ACVRLK3 | ||
| BMPR1A/ALK-3/CD292 protein is expressed in the epithelium during branching morphogenesis. It is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta (TGF-β) superfamily. BMPR1A/ALK-3 plays an essential role in the formation of embryonic ventral abdominal wall, and abrogation of BMP signaling activity due to gene mutations in its signaling components could be one of the underlying causes of omphalocele at birth. The type IA BMP receptor, ALK-3 was specifically required at mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum, and endocardial cushion. | ||
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